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Anxiety, depression, and inflammation after restorative proctocolectomy

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Anxiety and depression (A&D) are more common in inflammatory bowel disease (IBD) and in IBD patients who undergo proctocolectomy with ileal pouch-anal anastomosis (IPAA). Our aim was to test the hypothesis that chronic inflammatory conditions in IPAA are associated with increased incidence of A&D.

Methods

Retrospective cohort study at a single tertiary care referral center using a consented IBD and colon cancer natural history registry. Demographic and clinical factors, including surgical and psychiatric history, were abstracted.

Results

We compared A&D rate in three cohorts: (1) ulcerative proctocolitis with IPAA (UC) (n = 353), (2) Crohn’s disease/indeterminate proctocolitis with IPAA (CDIC) (n = 49), and (3) familial adenomatous polyposis with IPAA (FAP) (n = 33). Forty-six CDIC patients (93.9%) demonstrated pouch-related inflammation, while 126 UC patients (35.7%) and 2 FAP patients (6.1%) developed pouchitis. CDIC had a higher rate of A&D co-diagnosis compared to UC and FAP (20.4 vs.12.7 vs.12.1% respectively; p < 0.05). UC patients with pouchitis also exhibited a higher rate of A&D than UC without pouchitis (19.8 vs.8.8%; p < 0.05). Multivariable analysis demonstrated that pre-operative corticosteroid use (OR = 4.46, CI = 1.34–14.87, p < 0.05), female gender (OR = 2.19, CI = 1.22–3.95, p < 0.01), tobacco use (OR = 2.92, CI = 1.57 = 5.41, p < 0.001), and pouch inflammation (OR = 2.37, CI = 1.28–4.39, p < 0.05) were each independently associated with A&D in these patients.

Conclusions

Anxiety and depression were more common in patients experiencing inflammatory conditions of the pouch. UC without pouchitis and FAP patients demonstrated lower rates of A&D (that were comparable to the general population), implying that having an IPAA alone was not enough to increase risk for A&D. Factors independently associated with A&D in IPAA included an inflamed pouch, corticosteroid use, smoking, and female gender.

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Acknowledgments

The authors would like to thank Susan Deiling and Leonard Harris for their outstanding technical assistance in the procurement of data associated with this study.

Source of funding

This research was supported by the Peter and Marsha Carlino Early Career Professorship in Inflammatory Bowel Disease and the Margot E. Walrath Career Development Professorship in Gastroenterology.

Author information

Authors and Affiliations

  1. Department of Medicine, Penn State College of Medicine, Hershey, PA, USA

    Venkata Subhash Gorrepati

  2. Department of Psychiatry, Penn State College of Medicine, Hershey, PA, USA

    Sanjay Yadav

  3. Department of Medicine, Division of Gastroenterology and Hepatology, Penn State College of Medicine, Hershey, PA, USA

    August Stuart, Emmanuelle D. Williams & Matthew D. Coates

  4. Department of Surgery, Division of Colorectal Surgery, Penn State College of Medicine, Hershey, PA, USA

    Walter Koltun & Evangelos Messaris

Authors
  1. Venkata Subhash Gorrepati
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  2. Sanjay Yadav
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  3. August Stuart
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  4. Walter Koltun
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  5. Evangelos Messaris
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  7. Matthew D. Coates
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Corresponding author

Correspondence to Matthew D. Coates.

Ethics declarations

This study was approved by the Pennsylvania State University College of Medicine Institutional Review Board and conducted in accordance with their guidelines.

Conflict of interest

The authors declare that they have no conflict of interest.

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Gorrepati, V.S., Yadav, S., Stuart, A. et al. Anxiety, depression, and inflammation after restorative proctocolectomy. Int J Colorectal Dis 33, 1601–1606 (2018). https://doi.org/10.1007/s00384-018-3110-y

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  • DOI: https://doi.org/10.1007/s00384-018-3110-y

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