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International Journal of Colorectal Disease

, Volume 33, Issue 9, pp 1235–1240 | Cite as

Various clinicopathological features of patients with metachronous colorectal cancer in relation to different diagnostic intervals

  • Po-Yen Lin
  • Jy-Ming Chiang
  • Hsin-Yun Huang
  • Jeng-Fu You
  • Sum-Fu Chiang
  • Pao-Shiu Hsieh
  • Chien-Yuh Yeh
  • Rei-Ping Tang
Original Article

Abstract

Backgrounds

Clinicopathologic factors relating to developing metachronous colorectal cancer (CRC) have been reported. However, the effects of different diagnostic intervals on these risk factors required further analysis.

Patients and methods

This retrospective study comprised 14,481 patients diagnosed from January 1995 to December 2012. Metachronous CRC was defined as the occurrence of a second colorectal cancer at least 1 year post-operatively.

Results

A total of 153 (1.06%) patients developed metachronous CRCs during the follow-up. Significantly higher rates of developing metachronous cancer occurred in male patients (1.2 vs 0.9%), patients with synchronous CRC (2.0 vs 1.0%), and patients with a positive family history of CRC (1.4 vs 0.9%). Pertaining to diagnostic intervals related to clinicopathological features, more severe staging was significant in the diagnostic interval between 2 and 3 years (35 vs 7.7%, 20.6%, 17.5%, P = .01) compared with other intervals. Male patients were more frequently detected to have CRC within 3 years compared with females (53.1 vs 29.1%, P = .005). For a diagnostic interval ≧ 5 years, a significantly higher rate of metachronous CRC located at the right colon was observed than that located at the left colon (36.6 vs 19.7%, p = 0.03).

Conclusions

We evinced that a diagnostic interval between 2 and 3 years was a key time for metachronous CRC diagnosis with worse staging distribution. Based on current findings, we recommend the stratification of metachronous CRCs into diagnostic intervals of 1–2, 2–3, and ≧ 3 years, as they exhibit significantly different characteristics.

Keywords

Metachronous CRC Diagnostic interval 

Notes

Acknowledgements

This manuscript was edited by Wallace Academic Editing.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Po-Yen Lin
    • 1
  • Jy-Ming Chiang
    • 2
    • 3
    • 4
  • Hsin-Yun Huang
    • 2
    • 3
  • Jeng-Fu You
    • 2
    • 3
  • Sum-Fu Chiang
    • 2
    • 3
  • Pao-Shiu Hsieh
    • 2
    • 3
  • Chien-Yuh Yeh
    • 2
    • 3
  • Rei-Ping Tang
    • 2
    • 3
  1. 1.Department of Surgery, Chang Gung Memorial Hospital, Cha-Yi Medical CenterCha-YiTaiwan
  2. 2.Division of Colon and Rectal Surgery, Department of Surgery, Lin-Kou Medical CenterChang Gung Memorial HospitalTao-YuanTaiwan
  3. 3.College of MedicineChang Gung UniversityTao-YuanTaiwan
  4. 4.Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, and College of MedicineChang Gung UniversityTao-YuanTaiwan

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