Pediatric Surgery International

, Volume 35, Issue 2, pp 187–191 | Cite as

Risk factors for the development of post-operative enterocolitis in short segment Hirschsprung’s disease

  • Patrick Ho Yu ChungEmail author
  • Michelle On Na Yu
  • Kenneth Kak Yuen Wong
  • Paul Kwong Hang Tam
Original Article


Aim of the study

The objective of this study is to identify risk factors associated with the development of post-operative enterocolitis (HAEC), in short segment Hirschsprung’s disease (HSCR-S).


A retrospective study was carried out for post-operative patients with HSCR-S from 1997 to 2017. HSCR-S was defined as the most proximal extension of aganglionosis limited to the sigmoid colon. An episode of HAEC was defined as the presence of (1) vomiting or explosive diarrhea; (2) abdominal distension; (3) fever and (4) leukocytosis. Risk factors for the development of HACE were determined using multivariate logistic regression.

Main results

The medical records of 96 patients were reviewed. The overall incidence of HAEC was 20.8% (n = 20) and 65.0% (n = 13) of HAEC occurred within the first year of operation. After a univariate logistic regression analysis, three risk factors for HAEC were identified: (1) presence of other major anomalies [OR: 1.43 (1.12–2.32), p = 0.041]; (2) creation of pre-operative defunctioning stoma [OR: 2.28 (1.47–3.23), p = 0.035]; (3) extension of aganglionosis to the sigmoid colon [OR: 1.89 (1.05–3.19), p = 0.049]. After multivariate logistic regression analysis, a significant association was demonstrated for creation of pre-operative defunctioning stoma [OR: 1.81 (1.08–3.22), p = 0.045] and extension of aganglionosis to the sigmoid colon [OR: 1.91 (1.37–2.98), p = 0.038].


The requirement of pre-operative defunctioning stoma and a more proximal extension of aganglionosis are risk factors for the development of post-operative HAEC in HSCR-S. Patients with these risk factors should be closely followed up especially during the first year after the operation.


Hirschsprung’s disease Enterocolitis Dysbiosis Defunctioning stoma 




Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no conflict of interests.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Patrick Ho Yu Chung
    • 1
    Email author
  • Michelle On Na Yu
    • 1
  • Kenneth Kak Yuen Wong
    • 1
  • Paul Kwong Hang Tam
    • 1
  1. 1.Division of Paediatric Surgery, Department of Surgery, Queen Mary Hospital, Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

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