The relationship of eosinophilia with outcomes of Hirschsprung disease in children

  • Richard SolaJr.
  • Ashwini S. Poola
  • Rmaah Memon
  • Vivekanand Singh
  • Richard J. Hendrickson
  • Shawn D. St. Peter
  • Jason D. FraserEmail author
Original Article



It has been postulated that children with Hirschsprung disease (HD) and mucosal eosinophilia have been thought to have poorer outcome, but supporting evidence is lacking. The objective of our study was to review the outcomes of children with HD and mucosal eosinophilia.


A single center, retrospective review was conducted on all patients diagnosed with HD between 1999 and 2016. Pathology specimens were evaluated for mucosal eosinophilia. Demographics, complications, and outcomes were analyzed.


A total of 100 patients were diagnosed with HD and 27 had mucosal eosinophilia. Median age at the time of surgery was 12 days (8, 30) and 82 were males. Comparing patients with HD with and without mucosal eosinophilia, there was no statistically significant difference in time to bowel function (2 days vs. 2 days; p = 0.85), time to start feeds (3 days vs. 3 days; p = 0.78) and time to goal feeds (5 days vs. 5 days; p = 0.47). There was no statistically significant difference in feeding issues (13% vs. 9%; p = 1.0) and stooling issues (60% vs. 50%; p = 0.38). There was no statistically significant difference in postoperative complications and readmissions rates (63% vs. 56%; p = 0.53).


Hirschsprung-associated mucosal eosinophilia may not increase postoperative complications, and may not change feeding and bowel management. Further prospective studies are in process to evaluate long term follow-up outcomes for this patient population.


Hirschsprung disease Children Eosinophilia 


Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Richard SolaJr.
    • 1
  • Ashwini S. Poola
    • 1
  • Rmaah Memon
    • 1
  • Vivekanand Singh
    • 2
  • Richard J. Hendrickson
    • 1
  • Shawn D. St. Peter
    • 1
  • Jason D. Fraser
    • 1
    Email author
  1. 1.Department of General SurgeryThe Children’s Mercy Hospital and ClinicsKansas CityUSA
  2. 2.Department of PathologyThe Children’s Mercy HospitalKansas CityUSA

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