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Child's Nervous System

, Volume 35, Issue 12, pp 2405–2409 | Cite as

Non-convulsive status epilepticus in two patients with tuberous sclerosis

  • Yuksel ErdalEmail author
  • Alper Alnak
  • Ozgur Oztop
  • Pınar Tekturk
  • Zuhal Yapici
Case Report

Abstract

Tuberous sclerosis (TSC) is an autosomal dominantly inherited genetic disorder that chiefly affects the central nervous system, along with the other multiple systems. While phenomenology and symptom severity may vary greatly from one individual to another, the most common neurological presentation is epilepsy, which may be refractory in a considerable number of patients. Convulsive SE is seen frequently in TSC patients due to the high ratio of refractory seizures in well-studied cohorts. Status epilepticus (SE) is a life-threating condition and requires urgent medical care. Non-convulsive status epilepticus (NCSE) is an epileptic state with no convulsive seizures but impaired consciousness and corresponding electrophysiological findings. Due to its heterogeneity of clinical features, it is generally hard to recognize, and thus difficult to treat promptly. The relationship between TSC and NCSE is a relatively less emphasized issue in the literature. Here, we present two cases of TSC with NCSE with a view to increasing clinicians’ awareness of the association between refractory epilepsy and NCSE.

Keywords

Tuberous sclerosis Status epilepticus Non-convulsive status epilepticus mTOR inhibitors 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurologyHealth Science University, Istanbul Training and Research HospitalIstanbulTurkey
  2. 2.Department of Child and Adolescent PsychiatryIstanbul Faculty of Medicine, Istanbul UniversityIstanbulTurkey
  3. 3.Department of NeurologyFaculty of Medicine, Koc UniversityIstanbulTurkey
  4. 4.Division of Child Neurology, Department of NeurologyIstanbul Faculty of Medicine, Istanbul UniversityIstanbulTurkey

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