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The unseen third dimension: a novel approach for assessing head shape severity in infants with isolated sagittal synostosis

  • Rosalinda CalandrelliEmail author
  • Fabio Pilato
  • Luca Massimi
  • Marco Panfili
  • Concezio Di Rocco
  • Cesare Colosimo
Original Article

Abstract

Purpose

This study aimed to develop a novel approach to assess the severity of skull dysmorphology in infants with isolated sagittal synostosis (ISS) and its relationship with the surgical results.

Methods

We divided 66 infants with ISS into three groups by combining the scaphocephalic (SSI-A) and platycephalic (VLI) indices as descriptors of the relation between length, width, and height. We evaluated each skull for morphology as hyperdolichocephalic (< 66%) versus dolichocephalic (66–77%) and as hyperplatycephalic (< 78%) versus platycephalic skull (78–85%). A score system was developed as follows: 2 points for values < 66% and < 78% and 1 point for values between 66 and 77% and 78 and 85% in SSI-A and VLI, respectively. The overall score was calculated and it was used to classify our patients on a 4-point ordinal scale, according to the severity of head shape (2 = mild, 3 = moderate, 4 = severe).

Results

Thirty-two infants resulted in mild group, 17 in moderate group, and 17 in severe group. SSI-A and VLI were reduced according to the severity of ISS. We demonstrated a positive correlation between SSA-A and VLI in mild subgroup of patients while we found a negative correlation between SSA-A and VLI in moderate and in severe subgroups. Moreover, a positive correlation was found between severe subgroup and Sloan III class of surgical results.

Conclusion

This study describes a simple tool to better classify infants with ISS, considering the three-dimensional morphology of the skull, because it evaluates both the dolichocephalic and platycephalic component.

Keywords

Isolated sagittal synostosis Scaphocephalic index Platycephalic index Computer tomography Skull morphology 

Notes

Compliance with ethical standards

Conflict of interest

Rosalinda Calandrelli declares that she has no conflict of interest.

Fabio Pilato declares that he has no conflict of interest.

Luca Massimi declares that he has no conflict of interest.

Marco Panfili declares that he has no conflict of interest.

Concezio Di Rocco declares that he has no conflict of interest.

Cesare Colosimo declares that he is scientific consultant for Bracco Diagnostics Inc. and Bayer HealthCare.

Research involving human participants

Ethical approval: We declare that all procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Area diagnostica per immaginiFondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro CuoreRomeItaly
  2. 2.Area neuroscienzeFondazione Policlinico Universitario Agostino Gemelli IRCCSRomeItaly
  3. 3.International Neuroscience InstituteHannoverGermany

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