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Child's Nervous System

, Volume 35, Issue 11, pp 2205–2210 | Cite as

Intracranial infection in patients with myelomeningocele: profile and risk factors

  • Ambrose O. Anegbe
  • M. Temitayo ShokunbiEmail author
  • Toyin A Oyemolade
  • Oluwakemi A. Badejo
Original Article
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Abstract

Purpose

To describe the profile and determine the risk factors for the development of intracranial infections (ICI) in paediatric patients with myelomeningocele (MMC).

Methods

Retrospective analysis of data from the records of patients with MMC admitted into our hospital between January 2006 and December 2015.

Results

We managed a total of 688 paediatric non-trauma neurosurgical patients in our facility during the study period. 29.4% of these patients had MMC. We found the records for 49% of the patients. The male: female ratio was 1.3:1. Most of the MMCs were located in the lumbosacral region (71.7%). The lesion was ruptured in 42.4%, unruptured in 53.5%, and indeterminate in 4.0% of the patients. 48.5% of the MMCs were infected at presentation. Surgical repair of the spinal dysraphism was performed in 74.7% of the patients. Postoperative complications observed in our series include wound dehiscence, cerebrospinal fluid leak, and pseudomeningocele which occurred in 13.5%, 12.2%, and 2.7% of the operated cases of MMC respectively. 28.3% of the patients with MMC developed ICI during the course of hospitalization. 71.4% of patients with MMC-associated ICI had septic neural placode at the initial clinical evaluation. 70% of the patients who had wound dehiscence post-operatively developed ICI. Loculations and abscesses occurred only in patients who had surgical repair. A multivariate logistic regression analysis revealed that septic neural placode, hydrocephalus, a supra-lumbar location of the MMCs and surgical intervention were predictive of ICI (p < 0.05).

Conclusion

Infection of the neural placode, hydrocephalus, locations of the lesions above the lumbar region, and surgical repair were the statistically significant risk factors for ICI in our study population. The trending but statistically insignificant risk factors for ICI in our series may require further assessment with a larger sample size.

Keywords

Spina bifida cystica Meningitis Ventriculitis Spinal dysraphism 

Notes

Compliance with ethical standards

Conflict of interest

The author declares that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Ambrose O. Anegbe
    • 1
  • M. Temitayo Shokunbi
    • 1
    Email author
  • Toyin A Oyemolade
    • 1
  • Oluwakemi A. Badejo
    • 1
  1. 1.Division of Neurological Surgery, Department of Surgery, College of MedicineUniversity of IbadanIbadanNigeria

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