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Role of early and aggressive post-operative radiation therapy in improving outcome for pediatric central nervous system atypical teratoid/rhabdoid tumor

  • Wan-Chin Yang
  • Hsiu-Ju Yen
  • Muh-Lii Liang
  • Hsin-Hung Chen
  • Yi-Yen Lee
  • Tai-Tong Wong
  • Yu-Wen Hu
  • Yi-Wei ChenEmail author
Original Article
  • 33 Downloads

Abstract

Purpose

The purpose of the study is to evaluate possible prognostic factors and optimal management for pediatric atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system (CNS).

Methods

Twenty-eight pediatric patients with CNS AT/RT who were treated with radiation therapy (RT) as part of multimodality treatment regimens at a single institution (1996–2015) were reviewed. Survival outcomes were analyzed in relation to possible prognostic factors.

Results

The 28 patients analyzed were followed up for a median 48-month period. Median progression-free survival (PFS) was 11 months, and overall survival (OS) was 57 months. Patients < 3 years old had RT delayed for a longer period after surgery (p = 0.04), and the mean RT dose to tumor bed was lower (p < 0.01) than in patients ≥ 3 years old. In multivariate analysis, a higher primary tumor bed RT dose was identified as a favorable prognostic factor for both PFS (hazard ratio [HR] = 0.85 per gray, p < 0.01) and OS (HR = 0.92 per gray, p = 0.02). In addition, an interval between surgery and RT initiation > 2 months, with disease progression observed before RT, as compared with an interval ≤ 2 months without disease progression prior to RT, was associated with worse PFS (HR = 8.50, p < 0.01) and OS (HR = 5.27, p < 0.01).

Conclusions

Early and aggressive RT after surgery is critical for successful disease control in AT/RT patients. Conversely, a delay in RT until disease progression is observed that leads to unfavorable outcomes.

Keywords

High-dose chemotherapy Radiation dose Radiation therapy Time interval 

Notes

Acknowledgements

We would like to thank Taipei Veterans General Hospital pediatric CNS tumor group for assistance in this study.

Funding

No funding was received for this study.

Compliance with ethical standards

The study was conducted in accordance with the Declaration of Helsinki.

Ethical approval

The data of this study was extracted from database of pediatric brain tumors in Taipei Veterans General Hospital, and the study protocol was approved by the Institutional Review Board of the Taipei Veterans General Hospital. The IRB number is 97-07-05A.

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent to this study was obtained from the parents of all participants.

Supplementary material

381_2019_4126_MOESM1_ESM.pdf (425 kb)
ESM 1 (PDF 424 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Radiation Oncology, Department of OncologyTaipei Veterans General HospitalTaipeiRepublic of China
  2. 2.National Yang-Ming University School of MedicineTaipeiRepublic of China
  3. 3.Division of Pediatric Hematology and Oncology, Department of PediatricsTaipei Veterans General HospitalTaipeiRepublic of China
  4. 4.Division of Pediatric Neurosurgery, The Neurological InstituteTaipei Veterans General HospitalTaipeiRepublic of China
  5. 5.Department of NeurosurgeryTaipei Medical University Hospital, Taipei Medical UniversityTaipeiRepublic of China

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