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Child's Nervous System

, Volume 35, Issue 5, pp 865–869 | Cite as

Old drugs still work! Oral etoposide in a relapsed medulloblastoma

  • Marta Perez-Somarriba
  • Maitane Andión
  • Miguel A. López-Pino
  • Cinzia Lavarino
  • Luis Madero
  • Alvaro LassalettaEmail author
Case Report

Abstract

Medulloblastoma is the most common malignant brain tumor in children. Approximately 30% of children with medulloblastoma will progress or relapse despite being treated. New therapies have been proposed in recent years, including high-dose chemotherapy, immunotherapy, and targeted therapy. However, the best treatment for these patients remains unclear, and in this situation prognosis is poor. Oral etoposide has been used as a single agent or in combination for treating relapsed brain tumors since the 1990s. We report an 8-year-old patient with recurrent metastatic medulloblastoma who had an excellent response after treatment with oral etoposide, maintaining a great quality of life. As clinicians, we must always try to include our patients in clinical trials; however, when this is not possible, we should not forget that “old drugs” such as oral etoposide may work in some patients, with a good response of the tumor, and what is most important, providing the patient with a good quality of life.

Keywords

Oral etoposide Relapsed medulloblastoma Chemotherapy Children 

Abbreviations

MRI

Magnetic resonance imaging

VP

Ventriculo-peritoneal

VP-16

Etoposide

PR

Partial response

CR

Complete response

SD

Stable disease

PD

Progressive disease

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Marta Perez-Somarriba
    • 1
  • Maitane Andión
    • 1
  • Miguel A. López-Pino
    • 2
  • Cinzia Lavarino
    • 3
  • Luis Madero
    • 1
  • Alvaro Lassaletta
    • 1
    Email author
  1. 1.Department of Pediatric OncologyHospital Universitario Niño JesúsMadridSpain
  2. 2.Department of RadiologyHospital Universitario Niño JesúsMadridSpain
  3. 3.Developmental Tumor Biology LaboratoryHospital Sant Joan de DéuBarcelonaSpain

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