Arterial ischemic stroke (AIS) in childhood: clinical report from a single control center
- 134 Downloads
Stroke is the clinical designation for a rapidly developing loss of brain function due to an interruption in the blood supply to all or part of the brain. It is the third cause of death in adults and one of the top 10 causes in pediatric age.
The perinatal period of onset is the second only to adult age group in the incidence of stroke. Arterial ischemic stroke during childhood occurs most frequently in the perinatal period with an incidence of 1 out 2300–5000 live infant births.
Materials and methods
This is a retrospective study that includes 28 patients affected by perinatal arterial ischemic stroke. Family and gestational history, risk factors of perinatal stroke, gender and clinical data of affected children and outcome are reported.
A stroke family history was registered in three unrelated families. Gestational history disclosed cases of threats of abortion, preterm delivery, hyperthermia, gestosis, and placental disorders. In the children, onset of seizures were reported within 3 days of life and diagnosis of stroke was confirmed by brain MRI which disclosed involvement of the middle cerebral artery in all the cases. Hemilateral cerebral palsy, epileptic seizures, and intellectual disability from mild to severe were the most frequent complications.
Stroke is still a common and dreadful events in perinatal period as this disorder is often unpredictable and cause of severe neurological impairment.
KeywordsStroke Seizures Neurological impairment Cerebral palsy
The authors wish to thank American Manuscript Editors (USA) for editing the manuscript. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.
Compliance with ethical standards
Conflicts of interest
There are no conflicts of interest.
- 8.Osler W (1987) The cerebral palsies of children. Mac Keith Press. Blackwell Scientific Publications, OxfordGoogle Scholar
- 9.Freud S (1968) Infantile cerebral paralysis. University of Miami Press, Coral GablesGoogle Scholar
- 19.Roach ES, Golomb MR, Adams R, Biller J, Daniels S, Deveber G, Ferriero D, Jones BV, Kirkham FJ, Scott RM, Smith ER, American Heart Association Stroke Council, Council on Cardiovascular Disease in the Young (2008) Management of stroke in infants and children: a scientific statement from a special writing group of the American Hearth Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 39:2644–2691CrossRefGoogle Scholar
- 23.Suppiej A, Franzoi M, Gentilomo C et al (2008) High prevalence of inherited thrombophilia in ‘presumed peri-neonatal’ ischemic stroke. Eur J Haematol 80:71–75Google Scholar
- 31.Callaghan WM, MacDorman MF, Shapiro-Mendoza CK, Barfield WD (2017) Explaining the recent decrease in US infant mortality rate, 2007–2013. Am J Obstet Gynecol 216(1):73.e1–73.e8. https://doi.org/10.1016/j.ajog.2016.09.097
- 32.Lehman LL, Khoury JC, Taylor JM, Yeramaneni S, Sucharew H, Alwell K, Moomaw CJ, Peariso K, Flaherty M, Khatri P, Broderick JP, Kissela BM, Kleindorfer DO (2018) Pediatric stroke rates over 17 years: report from a population-based study. J Child Neurol 33(7):463–467Google Scholar