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Early intraventricular baclofen therapy (IVB) for children with dystonic and dysautonomic storm

  • Claudio Ruggiero
  • Giulia Meccariello
  • Pietro Spennato
  • Giuseppe Mirone
  • Stefania Graziano
  • Marco Gilone
  • Giuseppe Cinalli
Brief Communication

Abstract

Introduction

Intrathecal baclofen (ITB) is an effective treatment for managing primary and secondary dystonia. Intraventricular baclofen (IVB) was first developed to allow treating patients in which the use of ITB was difficult due to anatomic anomalies. After that, several studies indicate that intraventricular administration of baclofen, is more effective than ITB in refractory dystonia.

Clinical material

We report three cases of children with acute dystonic and dysautonomic storm, treated with IVB. The clinical outcome was satisfactory. The response to the treatment continued after the pump disconnection, suggesting that in this kind of cerebral dysregulations, short-term IVB is an effective treatment.

Conclusion

Early treatment with IVB may be an effective option in patients with post-anoxic dysautonomic and dystonic storm.

Keywords

Intraventricular baclofen therapy Dystonia Baclofen 

Notes

Compliance with ethical standards

Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pediatric NeurosurgerySantobono-Pausilipon Children’s HospitalNaplesItaly
  2. 2.Department Pediatric NeurologySantobono-Pausilipon Children’s HospitalNaplesItaly

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