Prevalence and demographic characteristics of comorbid epilepsy in children and adolescents with cerebral palsy: a nationwide population-based study
- 151 Downloads
The nationwide prevalence of cerebral palsy (CP) is unknown due to the lack of a population-based registration system for CP in Taiwan. This study was the largest nationwide, population-based, cross-sectional study to estimate the prevalence of CP, prevalence rates of comorbid epilepsy in patients with CP, and association with socioeconomic status (SES) in Taiwan. The crude prevalence rate and age- and gender-specific prevalence rates were estimated.
A total of 8419 patients with CP were enrolled, and the estimated prevalence of CP was 1.76‰ in the pediatric population and 1.51‰ and 1.98‰ in girls and boys, respectively. The prevalence rate of epilepsy in patients with CP was 29.8%.
The result revealed a higher prevalence of CP and epileptic CP in members of families with lower insurance premiums than those with higher insurance premiums and those from East Taiwan compared with those from other areas of Taiwan. Moreover, a higher prevalence of CP is shown in rural area than urban area.
SES and geographic variables were significantly associated with the risk of epilepsy in children with CP. Patients with epileptic CP had a higher odds ratio of several neuropsychiatric diseases, including mental retardation, ophthalmologic problems, hearing impairment, and hydrocephalus.
KeywordsPediatric epilepsy Socioeconomic status National Health Insurance
Compliance with ethical standards
This study was approved by and conducted in accordance with the Institutional Review Board of Kuang-Tien General Hospital.
Conflict of interest
The authors declare that they have no conflict of interest.
- 10.Sellier E, Uldall P, Calado E, Sigurdardottir S, Torrioli MG, Platt MJ, Cans C (2012) Epilepsy and cerebral palsy: characteristics and trends in children born in 1976-1998. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 16:48–55CrossRefGoogle Scholar
- 13.El-Tallawy HN, Farghaly WM, Shehata GA, Badry R, Rageh TA (2014) Epileptic and cognitive changes in children with cerebral palsy: an Egyptian study. Neuropsychiatr Dis Treat 10:971–975Google Scholar
- 19.Liu C-Y, Hung Y, Chuang Y, Chen Y, Weng W, Liu J, Liang K (2006) Incorporating development stratification of Taiwan townships into sampling design of large scale health interview survey. J Health Manag 4:1–22Google Scholar
- 24.Ashwal S, Russman BS, Blasco PA, Miller G, Sandler A, Shevell M, Stevenson R (2004) Practice parameter: diagnostic assessment of the child with cerebral palsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 62:851–863CrossRefGoogle Scholar
- 25.(2000) Surveillance of cerebral palsy in Europe: a collaboration of cerebral palsy surveys and registers. Surveillance of Cerebral Palsy in Europe (SCPE). Developmental Medicine Child Neurology 42: 816–824Google Scholar
- 30.Nissen S, Purssell E, Shaw K, Bailey C, Efstathiou N, Dunford C (2017) Impaired mobility associated with an increased likelihood of death in children: a systematic review. Journal of child health care : for professionals working with children in the hospital and community: 1367493517732839Google Scholar
- 36.King G, Imms C, Palisano R, Majnemer A, Chiarello L, Orlin M, Law M, Avery L (2013) Geographical patterns in the recreation and leisure participation of children and youth with cerebral palsy: a CAPE international collaborative network study. Developmental neurorehabilitation 16:196–206CrossRefGoogle Scholar
- 37.Wang CM, Chen CY, Leong CP, Wong MK (1992) Cerebral palsy investigation in South Taiwan. J Rehabilitation Med Republic China 20:113–117Google Scholar
- 48.Hirschberger RG, Kuban KCK, O'Shea TM, Joseph RM, Heeren T, Douglass LM, Stafstrom CE, Jara H, Frazier JA, Hirtz D, Rollins JV, Paneth N (2018) Co-occurrence and severity of neurodevelopmental burden (cognitive impairment, cerebral palsy, autism spectrum disorder, and epilepsy) at age ten years in children born extremely preterm. Pediatr Neurol 79:45–52CrossRefGoogle Scholar