Monitoring optic chiasmatic-hypothalamic glioma volumetric changes by MRI in children under clinical surveillance or chemotherapy
Optic pathway gliomas represent 5% of pediatric brain tumors and are typically low-grade lesions. Because of their unpredictable clinical course, adequate treatment approaches have been controversial, involving surveillance, surgery, chemotherapy, and radiotherapy. In this study, we use volumetric imaging to compare evolution of optic chiasmatic-hypothalamic gliomas (OCHG) treated with and without chemotherapy, analyzing tumor volume variation during the overall period.
A total of 45 brain MRI were retrospectively analyzed for 14 patients with OCHG. Volumetric assessment of the lesions was performed by a neuroradiologist, using software DISPLAY. OCHG patients were allocated into two groups: group 1 (n = 8) who underwent chemotherapy and group 2 (n = 6) who did not receive chemotherapy. Outcome analysis was performed comparing tumor volume evolution of these two groups.
The results showed a reduction of 4.4% of the volume of the lesions for group 1 after the end of chemotherapy, with an increase of 5.3% in volume in the late follow-up examination. For group 2, we found a slight reduction (5%) of the overall volume of the lesions, both with no statistical significance (p > 0.05).
From the limited series analyzed in this study, no significant differences were observed in relation to the volume change of lesions treated or not treated with chemotherapy. Larger prospective clinical trials are needed to better evaluate the effect of chemotherapy and radiological response of OCHG.
KeywordsOptic pathway gliomas (OPG) Radiology Pediatric neurosurgery Chemotherapy
Compliance with ethical standards
Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
- 3.Kornreich L et al (2001) Optic pathway glioma: correlation of imaging findings with the presence of neurofibromatosis. Am J Neuroradiol 22(10):1963–1969Google Scholar
- 23.Fisher MJ, et al. (2012) Visual outcomes in children with neurofibromatosis type 1–associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis. Neuro-oncology nos076Google Scholar
- 25.Taylor T, et al (2014) Radiological classification of optic pathway gliomas: experience of a modified functional classification system. Br J RadiolGoogle Scholar
- 34.Dempsey MF, Condon BR, Hadley DM (2005) Measurement of tumor “size” in recurrent malignant Glioma: 1D, 2D, or 3D? AJNR Am J Neuroradiol 26:770–776Google Scholar
- 35.Kanaly CW, Mehta AI, Ding D, Hoang JK, Kranz PG, Herndon JE II, Coan A, Crocker I, Waller AF, Friedman AH, Reardon DA, Sampson JH (2014) A novel, reproducible, and objective method for volumetric magnetic resonance imaging assessment of enhancing glioblastoma. J Neurosurg 121(3):536–542CrossRefGoogle Scholar
- 38.Chow DS, Qi J, Guo X, Miloushev VZ, Iwamoto FM, Bruce JN, Lassman AB, Schwartz LH, Lignelli A, Zhao B, Filippi CG (2014) Semiautomated volumetric measurement on postcontrast MR imaging for analysis of recurrent and residual disease in glioblastoma multiforme. Am J Neuroradiol 35(3):498–503CrossRefGoogle Scholar