Child's Nervous System

, Volume 34, Issue 9, pp 1651–1656 | Cite as

Diffusion profiling of tumor volumes using a histogram approach can predict proliferation and further microarchitectural features in medulloblastoma

  • Stefan SchobEmail author
  • Anne Beeskow
  • Julia Dieckow
  • Hans-Jonas Meyer
  • Matthias Krause
  • Clara Frydrychowicz
  • Franz-Wolfgang Hirsch
  • Alexey Surov
Original Paper



Medulloblastomas are the most common central nervous system tumors in childhood. Treatment and prognosis strongly depend on histology and transcriptomic profiling. However, the proliferative potential also has prognostical value. Our study aimed to investigate correlations between histogram profiling of diffusion-weighted images and further microarchitectural features.

Material and methods

Seven patients (age median 14.6 years, minimum 2 years, maximum 20 years; 5 male, 2 female) were included in this retrospective study. Using a Matlab-based analysis tool, histogram analysis of whole apparent diffusion coefficient (ADC) volumes was performed.


ADC entropy revealed a strong inverse correlation with the expression of the proliferation marker Ki67 (r = − 0.962, p = 0.009) and with total nuclear area (r = − 0.888, p = 0.044). Furthermore, ADC percentiles, most of all ADCp90, showed significant correlations with Ki67 expression (r = 0.902, p = 0.036).

Discussion and conclusion

Diffusion histogram profiling of medulloblastomas provides valuable in vivo information which potentially can be used for risk stratification and prognostication. First of all, entropy revealed to be the most promising imaging biomarker. However, further studies are warranted.


Medulloblastoma Diffusion-weighted imaging ADC histogram analysis Histopathologic features Ki-67 


Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department for NeuroradiologyUniversity Hospital LeipzigLeipzigGermany
  2. 2.Department for Pediatric RadiologyUniversity Hospital LeipzigLeipzigGermany
  3. 3.Department for OphthalmologyUniversity Hospital LeipzigLeipzigGermany
  4. 4.Clinic for Diagnostic and Interventional RadiologyUniversity Hospital LeipzigLeipzigGermany
  5. 5.Clinic and Policlinic for NeurosurgeryUniversity Hospital LeipzigLeipzigGermany
  6. 6.Department for NeuropathologyUniversity Hospital LeipzigLeipzigGermany

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