Child's Nervous System

, Volume 34, Issue 9, pp 1799–1801 | Cite as

Aggravation of seizures and status epilepticus after vagal nerve stimulation therapy: the first pediatric case and review of the literature

  • Ebru ArhanEmail author
  • Ayşe Serdaroğlu
  • Tuğba Hirfanoğlu
  • Gökhan Kurt
Case Report



We describe the first child with drug-resistant epilepsy in whom vagus nerve stimulation aggravated seizures and emerged status epilepticus after the increase in vagal nerve stimulation current output.


A 13-year-old girl presented with refractory secondary generalized focal epilepsy. Vagal nerve stimulator was implanted because of drug-resistant epilepsy. After the increase of vagal nerve stimulator current output to a relatively high level, the patient experienced seizure aggravation and status epilepticus.


We conclude that vagus nerve stimulation may induce paradoxical seizures and may lead to status epilepticus, similarly to some antiepileptic drugs.


Epilepsy Seizures Vagal nerve stimulation 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Ebru Arhan
    • 1
    • 2
    Email author
  • Ayşe Serdaroğlu
    • 1
  • Tuğba Hirfanoğlu
    • 1
  • Gökhan Kurt
    • 3
  1. 1.Department of Pediatric NeurologyGazi University School of MedicineAnkaraTurkey
  2. 2.Pediatric Neurology DepartmentGazi University Faculty of MedicineAnkaraTurkey
  3. 3.Department of NeurosurgeryGazi University School of MedicineAnkaraTurkey

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