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Factors affecting survival of medulloblastoma in children: the changing concept of management

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Abstract

Medulloblastoma (MB) is a type of malignant tumor arising only in the cerebellum that was first defined by Cushing and Bailey in 1920s. In this review paper, we trace the evolution of risk stratification and the correlated changing concept of management in the past years. Outcome analysis of the hospital series of the Taipei Veterans General Hospital, Cheng Hsin General Hospital, and Taipei Medical University Hospital was performed to correlate prognostic indicators with reported studies. The purpose is to provide clues for age-specific and risk-adjusted optimal, effective, but beneficial and protective treatment strategies of these tumors in children.

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Acknowledgments

We thank Ms. Ching-Wen Tsai and Dr. Yen-Kuang Lin at the Biostatistics Center, Taipei Medical University, Taipei, Taiwan for their contribution to the data analysis of this work.

Source of funding

This work was supported by the Ministry of Science and Technology, Taiwan (grant number NSC102-2314-B-038-060-MY3); Health and Welfare Surcharge of Tobacco Products, Taiwan (grant number MOHW104-TDU-B-212-124-001); and Taipei Medical University Hospital, Taipei, Taiwan (grant number 104TMU-TMUH-11).

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    Authors and Affiliations

    1. Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan

      Tai-Tong Wong & Sang-Hue Yen

    2. Department of Pediatrics, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan

      Yen-Lin Liu

    3. National Taiwan University and Academia Sinica, Taipei, Taiwan

      Yen-Lin Liu

    4. Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan

      Donald Ming-Tak Ho & Shih-Chieh Lin

    5. Department of Pediatrics, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan

      Kai-Ping Chang & Ting-Rong Hsu

    6. Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan

      Tai-Tong Wong, Muh-Lii Liang, Hsin-Hung Chen, Yi-Yen Lee & Wan-You Guo

    7. Department of Radiology, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, Taipei, Taiwan

      Feng-Chi Chang

    8. Department of Internal Medicine, Cheng Hsin General Hospital, Taipei, Taiwan

      Kuo-Wei Chen

    9. Department of Pathology, Cheng Hsin General Hospital, Taipei, Taiwan

      Wei-Kang Kwang

    10. Department of Radiology, Chen Hsin General Hospital, Taipei, Taiwan

      Wu-Yu Hou

    11. Department of Radiation Oncology, Cheng Hsin General Hospital, Taipei, Taiwan

      Chung-Yih Wang

    12. Department of Oncology, Taipei Veterans General Hospital and National Yang Ming University, School of Medicine, 201 Sec 2 Shi Pai Rd, Taipei, 11217, Taiwan

      Yi-Wei Chen

    13. Pediatric Neurosurgery, Department of Neurosurgery, Taipei Medical University Hospital, 252 Wuxing St, Taipei, 11031, Taiwan

      Tai-Tong Wong

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    1. Tai-Tong Wong
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    Correspondence to Tai-Tong Wong or Yi-Wei Chen.

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    Tai-Tong Wong, Yen-Lin Liu, Donald Ming-Tak Ho and Kai-Ping Chang contributed equally to this work.

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    Wong, TT., Liu, YL., Ho, D.MT. et al. Factors affecting survival of medulloblastoma in children: the changing concept of management. Childs Nerv Syst 31, 1687–1698 (2015). https://doi.org/10.1007/s00381-015-2884-2

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    • DOI: https://doi.org/10.1007/s00381-015-2884-2

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