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Heart and Vessels

, Volume 34, Issue 12, pp 1899–1908 | Cite as

Association of onset-season with characteristics and long-term outcomes in acute myocardial infarction patients: results from the Japanese registry of acute myocardial infarction diagnosed by universal definition (J-MINUET) substudy

  • Taishi Okuno
  • Jiro Aoki
  • Kengo TanabeEmail author
  • Koichi Nakao
  • Yukio Ozaki
  • Kazuo Kimura
  • Junya Ako
  • Teruo Noguchi
  • Satoshi Yasuda
  • Satoru Suwa
  • Kazuteru Fujimoto
  • Yasuharu Nakama
  • Takashi Morita
  • Wataru Shimizu
  • Yoshihiko Saito
  • Atsushi Hirohata
  • Yasuhiro Morita
  • Teruo Inoue
  • Atsunori Okamura
  • Toshiaki Mano
  • Kazuhito Hirata
  • Yoshisato Shibata
  • Mafumi Owa
  • Kenichi Tsujita
  • Hiroshi Funayama
  • Nobuaki Kokubu
  • Ken Kozuma
  • Shiro Uemura
  • Tetsuya Tobaru
  • Keijiro Saku
  • Shigeru Ohshima
  • Kunihiro Nishimura
  • Yoshihiro Miyamoto
  • Hisao Ogawa
  • Masaharu Ishihara
  • J-MINUET investigators
Original Article
  • 161 Downloads

Abstract

It is known that incidence and short-term mortality rate of acute myocardial infarction (AMI) tend to be higher in the cold season. The aim of our study was to investigate the association of onset-season with patient characteristics and long-term prognosis of AMI. This was a prospective, multicenter, Japanese investigation of 3,283 patients with AMI who were hospitalized within 48 h of symptom onset between July 2012 and March 2014. Patients were divided into 3 seasonal groups according to admission date: cold season group (December–March), hot season group (June–September), and moderate season group (April, May, October, and November). We identified 1356 patients (41.3%) admitted during the cold season, 901 (27.4%) during the hot season, and 1026 (31.3%) during the moderate season. We investigated the seasonal effect on patient characteristics and clinical outcomes. Baseline characteristics of each seasonal group were comparable, with the exception of age, Killip class, and conduction disturbances. The rates of higher Killip class and complete atrioventricular block were significantly higher in the cold season group. The 3-year cumulative survival free from major adverse cardiac events (MACE) rate was the lowest in the cold season (67.1%), showing a significant difference, followed by the moderate (70.0%) and hot seasons (72.9%) (p < 0.01). Initial severity and long-term prognoses were worse in patients admitted during the cold season. Our findings highlight the importance of optimal prevention and follow-up of AMI patients with cold season onset.

Keywords

Acute myocardial infarction Season Temperature Prognosis Japan 

Notes

Acknowledgements

The authors thank all the enrolled patients, participating cardiologists, medical and other staffs who have contributed to this study. This study was supported by the Intramural Research Fund, grant number 23–4-5, for Cardiovascular Diseases of the National Cerebral and Cardiovascular Center.

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Copyright information

© Springer Japan KK, part of Springer Nature 2019

Authors and Affiliations

  • Taishi Okuno
    • 1
  • Jiro Aoki
    • 1
  • Kengo Tanabe
    • 1
    Email author
  • Koichi Nakao
    • 2
  • Yukio Ozaki
    • 3
  • Kazuo Kimura
    • 4
  • Junya Ako
    • 5
  • Teruo Noguchi
    • 6
  • Satoshi Yasuda
    • 6
  • Satoru Suwa
    • 7
  • Kazuteru Fujimoto
    • 8
  • Yasuharu Nakama
    • 9
  • Takashi Morita
    • 10
  • Wataru Shimizu
    • 11
  • Yoshihiko Saito
    • 12
  • Atsushi Hirohata
    • 13
  • Yasuhiro Morita
    • 14
  • Teruo Inoue
    • 15
  • Atsunori Okamura
    • 16
  • Toshiaki Mano
    • 17
  • Kazuhito Hirata
    • 18
  • Yoshisato Shibata
    • 19
  • Mafumi Owa
    • 20
  • Kenichi Tsujita
    • 21
  • Hiroshi Funayama
    • 22
  • Nobuaki Kokubu
    • 23
  • Ken Kozuma
    • 24
  • Shiro Uemura
    • 25
  • Tetsuya Tobaru
    • 26
  • Keijiro Saku
    • 27
  • Shigeru Ohshima
    • 28
  • Kunihiro Nishimura
    • 29
  • Yoshihiro Miyamoto
    • 29
  • Hisao Ogawa
    • 30
  • Masaharu Ishihara
    • 31
  • J-MINUET investigators
  1. 1.Division of CardiologyMitsui Memorial HospitalTokyoJapan
  2. 2.Division of CardiologySaiseikai Kumamoto Hospital Cardiovascular CentreKumamotoJapan
  3. 3.Department of CardiologyFujita Health University HospitalToyoakeJapan
  4. 4.Cardiovascular CentreYokohama City University Medical CentreYokohamaJapan
  5. 5.Department of Cardiovascular MedicineKitasato UniversityTokyoJapan
  6. 6.Department of Cardiovascular MedicineNational Cerebral and Cardiovascular CentreOsakaJapan
  7. 7.Department of CardiologyJuntendo University Shizuoka HospitalShizuokaJapan
  8. 8.Department of CardiologyNational Hospital Organization Kumamoto Medical CentreKumamotoJapan
  9. 9.Department of CardiologyHiroshima City HospitalHiroshimaJapan
  10. 10.Division of CardiologyOsaka General Medical CentreOsakaJapan
  11. 11.Department of Cardiovascular Medicine, Nippon Medical SchoolTokyoJapan
  12. 12.First Department of Internal MedicineNara Medical UniversityNaraJapan
  13. 13.Department of Cardiovascular MedicineThe Sakakibara Heart Institute of OkayamaOkayamaJapan
  14. 14.Department of CardiologyOgaki Municipal HospitalOgakiJapan
  15. 15.Department of Cardiovascular MedicineDokkyo Medical UniversityTochigiJapan
  16. 16.Department of CardiologySakurabashi Watanabe HospitalOsakaJapan
  17. 17.Cardiovascular CentreKansai Rosai HospitalHyogoJapan
  18. 18.Department of CardiologyOkinawa Prefectural Chubu HospitalUrumaJapan
  19. 19.Department of CardiologyMiyazaki Medical Association HospitalMiyazakiJapan
  20. 20.Department of Cardiovascular MedicineSuwa Red Cross HospitalNaganoJapan
  21. 21.Department of Cardiovascular Medicine, Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan
  22. 22.Division of Cardiovascular Medicine, Saitama Medical CentreJichi Medical UniversityTochigiJapan
  23. 23.Department of Cardiovascular, Renal and Medabolic Medicine, Sapporo Medical SchoolSapporoJapan
  24. 24.Department of CardiologyTeikyo UniversityTokyoJapan
  25. 25.Department of Cardiology, Kawasaki Medical SchoolMatsushimaJapan
  26. 26.Department of CardiologySakakibara Heart InstituteTokyoJapan
  27. 27.Department of CardiologyFukuoka University School of MedicineFukuokaJapan
  28. 28.Department of CardiologyGunma Prefectural Cardiovascular CentreMaebashiJapan
  29. 29.Department of Preventive CardiologyNational Cerebral and Cardiovascular CentreOsakaJapan
  30. 30.National Cerebral and Cardiovascular CentreOsakaJapan
  31. 31.Division of Coronary Artery DiseaseHyogo College of MedicineNishinomiyaJapan

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