Chemokine (C–X–C motif) receptor 2 blockade by SB265610 inhibited angiotensin II-induced abdominal aortic aneurysm in Apo E−/− mice
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Inflammation plays a critical role in the development of abdominal aortic aneurysm (AAA). Chemokine receptor CXCR2 mediates inflammatory cell chemotaxis in several diseases. However, the role of CXCR2 in AAA and the underlying mechanisms remain unknown. In this study, we found that the CXCR2 expressions in AAA tissues from human and angiotensin II (Ang II)-infused apolipoprotein E knockout (Apo E−/−) mice were significantly increased. The pharmacological inhibition of CXCR2 (SB265610) markedly reduced Ang II-induced AAA formation. Furthermore, SB265610 treatment significantly reduced collagen deposition, elastin degradation, the metal matrix metalloprotease expression and accumulation of macrophage cells. In conclusion, these results showed CXCR2 plays a pathogenic role in AAA formation. Inhibition of CXCR2 pathway may represent a novel therapeutic approach to treat AAA.
KeywordsChemoreceptor CXCR2 AAA Inflammation Macrophage
Chemokine (C–X–C motif) receptor 2
Abdominal aortic aneurysms
- Ang II
Tumor necrosis factor-α
We would like to acknowledge funding support from The Natural Science Foundation of China (81770481) and CAMS Innovation Fund for Medical Sciences (CIFMS, 2017-12M-1-008).
Compliance with ethical standards
Conflict of interest
The authors declare that there are no competing or financial interests associated with the manuscript.
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