Heart and Vessels

, Volume 34, Issue 5, pp 842–850 | Cite as

Clinical significance of the timing of early recurrence of atrial arrhythmia after pulmonary vein isolation: a two-institution clinical study

  • Yosuke Murase
  • Yasuya IndenEmail author
  • Hajime Imai
  • Seifuku Kyo
  • Satoshi Yanagisawa
  • Aya Fujii
  • Yusuke Sakamoto
  • Toshiro Tomomatsu
  • Toyoaki Murohara
Original Article


Early recurrence of atrial arrhythmia (ERAA) after ablation frequently occurs, but there is limited evidence about ERAA-timing. This study aimed to investigate the association between ERAA-timing and late recurrence. We retrospectively investigated 332 patients who underwent PVI for paroxysmal atrial fibrillation at Nagoya University Hospital and Komaki City Hospital. Seventy-six patients (23%) had ERAA. The cutoff value of the first ERAA for late recurrence was set as 3 days, with a specificity of 77% and sensitivity of 43%. On multivariate analysis, first ERAA beyond 3 days (hazard ratio, 2.477; 95% confidence interval, 1.168–5.25; p = 0.018) and large left atrial diameter (LAD) (hazard ratio, 1.101; 95% confidence interval, 1.024–1.184; p = 0.009) were independent predictors for late recurrence. Patients who had first ERAA within 3 days and no ERAA beyond 3 days showed a significantly higher recurrence–free rate than those who had first ERAA beyond 3 days and those who had ERAA both within 3 days and beyond 3 days (89% versus 39%, 44%; p  < 0.001). Moreover, the patients with ERAA within 3 days and LAD ≤ 37.7 mm showed a significantly higher recurrence–free rate than those with ERAA beyond 3 days and LAD > 37.7 mm, and as compared with the other patients (100% versus 26% and 60%, respectively; p < 0.001). ERAA beyond 3 days after ablation was a predictor for late recurrence. Among patients with ERAA, those with ERAA within 3 days and smaller LAD showed favorable prognosis after ablation.


Paroxysmal atrial fibrillation Catheter ablation Early recurrence Atrial arrhythmia recurrence Left atrial diameter 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Yosuke Murase
    • 1
  • Yasuya Inden
    • 2
    Email author
  • Hajime Imai
    • 1
  • Seifuku Kyo
    • 1
  • Satoshi Yanagisawa
    • 2
  • Aya Fujii
    • 2
  • Yusuke Sakamoto
    • 2
  • Toshiro Tomomatsu
    • 2
  • Toyoaki Murohara
    • 2
  1. 1.Department of CardiologyKomaki City HospitalKomakiJapan
  2. 2.Department of CardiologyNagoya University Graduate School of MedicineNagoyaJapan

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