Heart and Vessels

, Volume 34, Issue 4, pp 572–582 | Cite as

Comparison of the vessel healing process after everolimus-eluting stent and bare metal stent implantations in patients with ST-elevation myocardial infarction

  • Hideki YanoEmail author
  • Shigeo Horinaka
  • Manami Watahik
  • Tomoko Watanabe
  • Toshihiko Ishimitsu
Original Article


Cobalt–chromium everolimus-eluting stent (CoCr EES) is associated with a lower rate of stent thrombosis even in patients with ST-elevation myocardial infarction (STEMI). However, the time-serial changes of endothelial coverage of the stent struts in the extremely early period have never been reported, especially in patients with STEMI. The aim of this study was to compare the vessel healing process between CoCr EES and cobalt–chromium bare metal stent (CoCr BMS) implantations using optical coherence tomography (OCT) in patients with STEMI. Sixty-three patients who had primary emergent percutaneous coronary intervention (PCI) with CoCr EES (42 patients) or CoCr BMS (21 patients) were enrolled in this study for 3 years. OCT was performed just after, 2 and 12 weeks after EES or BMS implantations. Time-serial changes in the neointimal coverage (NIC), the neointimal thickness, and malapposition of stent struts were evaluated. NIC of stent struts did not differ between CoCr EES (23.2%, 99.4%) and CoCr BMS (24.0%, 97.8%) at 2 weeks and 12 weeks after PCI, respectively. Thicknesses of the neointima on the stent strut was significantly thinner in CoCr EES (34.0 ± 13.8, 107.0 ± 32.4 µm) than in CoCr BMS (40.0 ± 14.6, 115.7 ± 33.8 µm) at 2 weeks and 12 weeks after PCI (= 0.011, p = 0.008), respectively. The malapposition did not differ just after PCI, and was completely resolved at 12 weeks after PCI in both groups. Thrombus was significantly less in CoCr EES than in CoCr BMS at 2 weeks (19.0% vs 42.9%, p < 0.01), and decreased over time in both groups, but at 12 weeks, disappeared only in CoCr EES (CoCr EES: 0% vs. CoCr BMS: 4.8%, p = 0.56). This study demonstrated that NIC and apposition of the stent struts almost completed at 12 weeks after EES and BMS implantations, while the neointimal thickness on the stent struts were thinner in EES than in BMS. Moreover, thrombus was significantly less in EES than in BMS implantations 2 weeks after PCI, which may explain the lower rate of acute and subacute stent thrombosis of EES compared with BMS.


Everolimus-eluting stent Optical coherence tomography ST-elevation myocardial infarction Neointimal thickness Apposition Stent strut coverage 


Compliance with ethical standards

Conflict of interest

The authors indicated no potential conflicts of interest.

Supplementary material

380_2018_1287_MOESM1_ESM.docx (30 kb)
Supplementary material 1 (docx 31 KB)


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Copyright information

© Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Hideki Yano
    • 1
    • 2
    Email author
  • Shigeo Horinaka
    • 1
  • Manami Watahik
    • 1
  • Tomoko Watanabe
    • 1
  • Toshihiko Ishimitsu
    • 1
  1. 1.Department of Cardiology and NephrologyDokkyo Medical University HospitalMibuJapan
  2. 2.Department of CardiologyNasu Red Cross HospitalOhtawaraJapan

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