Heart and Vessels

, Volume 34, Issue 4, pp 698–710 | Cite as

Randomized trial of an increased dose of calcium channel blocker or angiotensin II type 1 receptor blocker as an add-on intensive depressor therapy in type 2 diabetes mellitus patients with uncontrolled essential hypertension: the ACADEMIE Study

  • Satoshi Imaizumi
  • Yuhei Shiga
  • Masahiro Ogawa
  • Hideto Sako
  • Yoshihisa Nagata
  • Akira Matsunaga
  • Tetsuro Shirotani
  • Fumihiro Hoshino
  • Eiji Yahiro
  • Yuko Uehara
  • Natsumi Morito
  • Hiroyuki Tanigawa
  • Dai Shimono
  • Mikio Fukushima
  • Hidekazu Sugihara
  • Kenji Norimatsu
  • Takaaki Kusumoto
  • Keijiro Saku
  • Shin-ichiro MiuraEmail author
  • ACADEMIE Study Investigators
Original Article


There is a lack of data on how to treat hypertensive patients with diabetes when treatment with medium doses of calcium channel blocker and angiotensin II type 1 receptor blocker (ARB) is insufficient to achieve the target blood pressure (BP). A total of 121 participants with type 2 diabetes and uncontrolled essential hypertension, who were receiving medium doses of amlodipine (5 mg/day) and ARB, were enrolled. Participants were randomized to receive either a high dose of amlodipine (10 mg/day) plus a medium dose of ARB (high-AML) or a medium dose of amlodipine (5 mg/day) plus a high dose of ARB (high-ARB). The depressor effects of these two regimens were monitored using a telemonitoring home BP-measuring system. Fifty-four patients were excluded after an observation period, and the remaining 67 eligible participants were randomized into the two groups; 42 which had a record of their home BP for analysis. The change in morning home systolic and diastolic BP was greater in the high-AML than in the high-ARB (systolic BP; − 7.9 mmHg vs. + 2.7 mmHg; p = 0.0002, diastolic BP; − 3.9 mmHg vs. + 0.6 mmHg; p = 0.0007). In addition, the home systolic and diastolic BP before going to bed and office systolic BP were significantly reduced from week 0 only in the high-AML. An increased dose of amlodipine, but not ARB, reduced home morning BP in hypertensive patients with type 2 diabetes who were already receiving combination therapy with medium doses of amlodipine and ARB.


Angiotensin II type 1 receptor blocker Calcium channel blocker Essential Hypertension Home blood pressure Type 2 diabetes mellitus 



ACADEMIE Investigators (Munehito Ideishi, Atsushi Iwata, Keita Noda, Kanta Fujimi, Akira Kawamura, Sen Adachi, Hiroaki Nishikawa, Takao Fukushima, Nobuhide Tanaka, Kazuhiro Fujisawa, Yosuke Takamiya, Hiroaki Arishima, Toshihiro Shimokawa, Hiroshi Seto, Asao Inoue, Takemasa Midorikawa, Hiroshi Shijo)

Compliance with ethical standards

Conflict of interest

The ACADEMIE trial was sponsored by Sumitomo Dainippon Pharma Co., Ltd. K.S. is a Chief Director and S.M. is a Director of NPO Clinical and Applied Science, Fukuoka, Japan. K.S. has an Endowed “Department of Molecular Cardiovascular Therapeutics” supported by MSD, Co. LTD. S.M. belongs to the Department of Molecular Cardiovascular Therapeutics, which is supported by MSD, Co. LTD. K.S. and S.M. have received grants and lecture honoraria from Daiichi-Sankyo Co, Takeda Pharm. Co. Ltd., Bayer Yakuhin Pharm., and Astellas Pharma Inc.


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Copyright information

© Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Satoshi Imaizumi
    • 1
    • 2
  • Yuhei Shiga
    • 1
  • Masahiro Ogawa
    • 1
  • Hideto Sako
    • 1
  • Yoshihisa Nagata
    • 1
  • Akira Matsunaga
    • 3
  • Tetsuro Shirotani
    • 4
  • Fumihiro Hoshino
    • 5
  • Eiji Yahiro
    • 6
  • Yuko Uehara
    • 7
  • Natsumi Morito
    • 1
  • Hiroyuki Tanigawa
    • 8
  • Dai Shimono
    • 9
  • Mikio Fukushima
    • 10
  • Hidekazu Sugihara
    • 11
  • Kenji Norimatsu
    • 12
  • Takaaki Kusumoto
    • 12
  • Keijiro Saku
    • 1
    • 13
  • Shin-ichiro Miura
    • 1
    • 13
    Email author
  • ACADEMIE Study Investigators
  1. 1.Department of CardiologyFukuoka University School of MedicineFukuokaJapan
  2. 2.Clinical Research and Ethics CenterFukuoka University School of MedicineFukuokaJapan
  3. 3.Department of Laboratory MedicineFukuoka University School of MedicineFukuokaJapan
  4. 4.Shirotani HospitalFukuokaJapan
  5. 5.Murakami Karindoh HospitalFukuokaJapan
  6. 6.Fukuoka University Medical Education CenterFukuoka University School of MedicineFukuokaJapan
  7. 7.Showa HospitalFukuokaJapan
  8. 8.Tanigawa HospitalNagasakiJapan
  9. 9.Futata Tetsuhiro ClinicFukuokaJapan
  10. 10.Fukushima HospitalOitaJapan
  11. 11.Fukuseikai HospitalFukuokaJapan
  12. 12.Izumi General Medical CenterKagoshimaJapan
  13. 13.Department of Molecular Cardiovascular TherapeuticsFukuoka University School of MedicineFukuokaJapan

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