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Heart and Vessels

, Volume 34, Issue 2, pp 237–250 | Cite as

Two-year clinical outcomes of zotarolimus- and everolimus-eluting durable-polymer-coated stents versus biolimus-eluting biodegradable-polymer-coated stent in patients with acute myocardial infarction with dyslipidemia after percutaneous coronary intervention: data from the KAMIR

  • Yong Hoon KimEmail author
  • Ae-Young Her
  • Myung Ho Jeong
  • Byeong-Keuk Kim
  • Sung-Jin Hong
  • Dong-Ho Shin
  • Jung-Sun Kim
  • Young-Guk Ko
  • Donghoon Choi
  • Myeong-Ki Hong
  • Yangsoo Jang
Original Article
  • 81 Downloads

Abstract

There are limited data comparing the clinical outcomes among new-generation drug-eluting stents (DES) in acute myocardial infarction (AMI) patients with dyslipidemia after percutaneous coronary intervention (PCI). We thought to investigate 2-year clinical outcomes among durable-polymer (DP)-coated stents [zotarolimus eluting (ZES) and everolimus eluting (EES)] and biodegradable-polymer (BP)-coated biolimus-eluting stent (BES) in dyslipidemic AMI patients after PCI. Finally, a total 2403 enrolled patients were divided into ZES (n = 953), EES (n = 1145) or BES (n = 305) group. The primary endpoint was major adverse cardiac events (MACE) defined as total death (TD), cardiac death (CD), myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR) and non-TVR. The secondary endpoint was the incidence of definite or probable stent thrombosis (ST). The 2-year adjusted hazard ratio (HR) of MACE for ZES vs. EES [HR, 1.066; 95% confidence interval (CI) 0.752–1.511; p = 0.720], ZES vs. BES (HR 0.933; 95% CI 0.565–1.541; p = 0.786), EES vs. BES (HR 1.876; 95% CI 0.535–1.436; p = 0.600) and ZES/EES vs. BES (HR 0.929; 95% CI 0.591–1.462; p = 0.751) was similar. The cumulative incidences of ST were comparable (ZES vs. EES vs. BES = 1.1% vs. 0.9% vs. 1.1%, p = 0.675) and adjusted HR was not different. In addition, the 2-year adjusted HR of TD, CD, MI, TLR, TVR, and non-TVR was similar. The AMI patients with dyslipidemia receiving ZES, EES, or BES after PCI showed comparable safety and efficacy during 2-year follow-up periods. Therefore, DP-DES or BP-DES is equally acceptable in dyslipidemic AMI patients during PCI.

Keywords

Myocardial infarction Dyslipidemia Drug-eluting stents 

Abbreviations

AMI

Acute myocardial infarction

BES

Biolimus-eluting stents

BP

Biodegradable polymer

DES

Drug-eluting stents

DP

Durable polymer

EEE

Everolimus-eluting stent

MACE

Major adverse cardiac events

PCI

Percutaneous coronary intervention

PES

Paclitaxel-eluting stent

SES

Sirolimus-eluting stent

ST

Stent thrombosis

TLR

Target lesion revascularization

TVR

Target vessel revascularization

ZES

Zotarolimus-eluting stent

Notes

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest relevant to this article to disclose.

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Copyright information

© Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Yong Hoon Kim
    • 1
    Email author
  • Ae-Young Her
    • 1
  • Myung Ho Jeong
    • 2
  • Byeong-Keuk Kim
    • 3
  • Sung-Jin Hong
    • 3
  • Dong-Ho Shin
    • 3
  • Jung-Sun Kim
    • 3
  • Young-Guk Ko
    • 3
  • Donghoon Choi
    • 3
  • Myeong-Ki Hong
    • 3
  • Yangsoo Jang
    • 3
  1. 1.Division of Cardiology, Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea
  2. 2.Chonnam National University HospitalGwangjuRepublic of Korea
  3. 3.Division of Cardiology, Severance Cardiovascular HospitalYonsei University College of MedicineSeoulSouth Korea

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