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Cardiac function adaptations in hibernating grizzly bears (Ursus arctos horribilis)

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Abstract

Research on the cardiovascular physiology of hibernating mammals may provide insight into evolutionary adaptations; however, anesthesia used to handle wild animals may affect the cardiovascular parameters of interest. To overcome these potential biases, we investigated the functional cardiac phenotype of the hibernating grizzly bear (Ursus arctos horribilis) during the active, transitional and hibernating phases over a 4 year period in conscious rather than anesthetized bears. The bears were captive born and serially studied from the age of 5 months to 4 years. Heart rate was significantly different from active (82.6 ± 7.7 beats/min) to hibernating states (17.8 ± 2.8 beats/min). There was no difference from the active to the hibernating state in diastolic and stroke volume parameters or in left atrial area. Left ventricular volume:mass was significantly increased during hibernation indicating decreased ventricular mass. Ejection fraction of the left ventricle was not different between active and hibernating states. In contrast, total left atrial emptying fraction was significantly reduced during hibernation (17.8 ± 2.8%) as compared to the active state (40.8 ± 1.9%). Reduced atrial chamber function was also supported by reduced atrial contraction blood flow velocities and atrial contraction ejection fraction during hibernation; 7.1 ± 2.8% as compared to 20.7 ± 3% during the active state. Changes in the diastolic cardiac filling cycle, especially atrial chamber contribution to ventricular filling, appear to be the most prominent macroscopic functional change during hibernation. Thus, we propose that these changes in atrial chamber function constitute a major adaptation during hibernation which allows the myocardium to conserve energy, avoid chamber dilation and remain healthy during a period of extremely low heart rates. These findings will aid in rational approaches to identifying underlying molecular mechanisms.

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Acknowledgments

This work was supported by the Autzen Foundation and the Washington State University Bear Research Education and Conservation Center. We thank the graduate students Jennifer Fortin and Justin Teisburg, and technologists, Gary Radamaker, and Pam Thompson at Washington State University for excellent technical assistance and management of bear care.

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Correspondence to O. Lynne Nelson.

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Communicated by H. V. Carey.

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Nelson, O.L., Robbins, C.T. Cardiac function adaptations in hibernating grizzly bears (Ursus arctos horribilis). J Comp Physiol B 180, 465–473 (2010). https://doi.org/10.1007/s00360-009-0421-x

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Keywords

  • Atrial chamber
  • Bradycardia
  • Cardiac function
  • Diastolic function
  • Ursus arctos horribilis