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Journal of Comparative Physiology A

, Volume 197, Issue 1, pp 25–32 | Cite as

Serotonergic cerebral cells control activity of cilia in the foregut of the pteropod mollusk Clione limacina

  • Aleksey Y. MalyshevEmail author
  • Pavel M. Balaban
Original Paper

Abstract

Bilaterally symmetrical pair of serotonergic cells, named C1 in Clione, has been described in the cerebral ganglia of all gastropod species. Here we describe a new role of C1 cells in gastropod mollusks: control of activity of ciliated epithelium in the foregut. Detailed morphological investigation of C1 neurons in the pteropod mollusk Clione limacina revealed that these cells among other destinations send their neurites into foregut where they produce intense arborization with large varicosities along the processes. Intracellular stimulation of a single C1 induced pronounced activation (often followed by inhibition) of cilia lining the foregut. This activation was substantially reduced by serotonin antagonist mianserin. Bath application of serotonin also induced transient increase in ciliary transport rate, followed by inhibition of ciliary activity up to its full cessation in some areas of isolated foregut. These data suggest that C1 in Clione may use serotonin to influence cilia in the foregut. Taking into account high homology of serotonergic cerebral cells across studied species we can speculate that these cells may be involved in the neural control of cilia in the foregut in other gastropod mollusks.

Keywords

Mollusk Neuron Cilia Foregut Serotonin 

Notes

Acknowledgments

This study was supported by Russian Foundation for Basic Reseach, Council for Grants of the President of RF and Federal Program of Russian Ministry of Education and Science.

Supplementary material

359_2010_581_MOESM1_ESM.mpg (10.6 mb)
Supplementary material 1 (MPG 10805 kb)

Supplementary material 2 (MPG 5458 kb)

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia

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