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Messung der glaukomspezifischen Funktionsfähigkeit mit dem GQL-15 und Korrelation mit Funktionsparametern des Sehens

Measurement of glaucoma-specific functionality with the GQL-15 and correlation with parameters of visual function

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Zusammenfassung

Einleitung

Das Glaukom zählt zu den häufigsten Ursachen irreversibler Erblindung weltweit und kann die Lebensqualität und Funktionsfähigkeit betroffener Patienten signifikant beeinträchtigen. Mit dem englischsprachigen „Glaucoma Quality of Life-15“ (GQL-15) steht seit geraumer Zeit ein spezialisiertes Instrument zur Quantifizierung der funktionellen Beeinträchtigung von Glaukompatienten zur Verfügung. Diese Studie evaluiert eine deutschsprachige Version des GQL-15 und stellt Korrelationen zu Gesichtsfeldparametern her.

Methoden

Eine deutschsprachige Version des GQL-15 mit 15 Items wurde erstellt und an 98 Glaukompatienten in verschiedenen Stadien der Erkrankung evaluiert. Die Ergebnisse des GQL-15 wurden mit perimetrischen Parametern [“mean deviation“ (MD), „pattern standard deviation“ (PSD)] des jeweils besseren und schlechteren Auges korreliert, und es wurde ein lineares Regressionsmodell berechnet. Klassische und probabilistische Testprüfungen (Rasch-Analyse) wurden durchgeführt.

Ergebnisse

Der mittlere GQL-15-Wert aus 15 Fragen (Items) betrug 77,3 ±21,7 (SA). Für die meisten Items zeigte sich eine signifikante Korrelation mit der mittleren Empfindlichkeit des schlechteren (r = −0,416; p = 0,0014) und des besseren Auges (r = −0,304; p = 0,02). Insgesamt korrelierte die glaukombedingte visuelle Funktionseinschränkung besonders gut mit der Empfindlichkeitsminderung des schlechteren Auges und mit der Sehschärfe. Zudem kann eine Kürzung des Fragebogens auf 9 Items erfolgen, um die psychometrischen Eigenschaften zu verbessern.

Zusammenfassung

Der GQL-15 ist ein nach psychometrischer Analyse verlässliches Instrument zur Erfassung der visuellen Funktionseinschränkung von Patienten mit Glaukom. Die GQL-Werte korrelierten in dieser Studie besser mit der Empfindlichkeitsminderung des schlechteren als des besseren Auges. Die gewonnenen Daten ermöglichen es, die Beeinträchtigung des individuellen Patienten besser einzuordnen, und können helfen, die Beratung und Therapie von Patienten mit Glaukom zu verbessern.

Abstract

Introduction

Glaucoma is one of the leading causes of irreversible blindness worldwide and can have a significant impact on patient quality of life and vision-related functioning. The Glaucoma Quality of Life 15 (GQL-15) questionnaire is a disease-specific instrument to evaluate and quantify functional impairment of patients with glaucoma. This study evaluated the German version of the GQL-15 including correlations with perimetric parameters.

Methods

A German version of the GQL-15 containing 15 items was developed and evaluated in 98 patients with glaucoma in different stages of the disease. The GQL-15 results were correlated with the perimetric parameters mean deviation (MD) and pattern standard deviation (PSD) of the better and worse eye. Classical and probabilistic test analyses (Rasch model) were performed.

Results

The mean GQL-15 value was 77.3 ±21.7 (SD) and most items of the GQL-15 correlated significantly with the MD of the worse eye (r = −0.416; p = 0.0014) and the better eye (r = −0.304; p = 0.02). There was also a highly significant correlation between glaucoma-specific QoL and visual acuity. A short version containing nine items yielding a higher psychometric performance can also be used.

Conclusions

The German version of the GQL-15 is a potent instrument to evaluate impairment in vision-specific functioning of patients with glaucoma. The GQL-15 values are better correlated with the sensitivity of the eye with the more severe glaucomatous damage. The data can help for a better understanding of individual patient impairment to improve medical advice and therapy of patients with glaucoma.

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Authors and Affiliations

  1. Augenklinik, Ludwig-Maximilians-Universität München, München, Deutschland

    C. Hirneiß, M. Vogel, A. Kampik, A.S. Neubauer & M. Kernt

  2. Augenklinik der LMU , Klinikum der Universität München Campus Innenstadt, Mathildenstr. 8, 80336, München, Deutschland

    C. Hirneiß

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  1. C. Hirneiß
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  2. M. Vogel
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Correspondence to C. Hirneiß.

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Hirneiß, C., Vogel, M., Kampik, A. et al. Messung der glaukomspezifischen Funktionsfähigkeit mit dem GQL-15 und Korrelation mit Funktionsparametern des Sehens. Ophthalmologe 108, 939–946 (2011). https://doi.org/10.1007/s00347-011-2402-1

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