Meta-analysis of efficacy and safety of continuous saline bladder irrigation compared with intravesical chemotherapy after transurethral resection of bladder tumors

  • Zhongbao Zhou
  • Shikai Zhao
  • Youyi Lu
  • Jitao Wu
  • Yongwei Li
  • Zhenli Gao
  • Diandong YangEmail author
  • Yuanshan CuiEmail author



We performed a meta-analysis to confirm the efficacy and safety of continuous saline bladder irrigation compared with intravesical chemotherapy after transurethral resection for the treatment of non-muscle invasive bladder cancer.


Randomized controlled trials of continuous saline bladder irrigation compared with intravesical chemotherapy were searched using MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The data were evaluated and statistically analyzed using RevMan version 5.3.0.


Four studies including 861 participants which compared continuous saline bladder irrigation with intravesical chemotherapy were considered. One-year recurrence-free survival [odds ratio (OR) = 0.76, 95% CI = 0.55–1.05, p = 0.09]; 2-year recurrence-free survival (OR = 0.94, 95% CI = 0.71–1.25, p = 0.68); the median period to first recurrence (OR = − 1.01, 95% CI = − 2.96 to 0.94, p = 0.31); the number of tumor progression (OR = 0.80, 95% CI = 0.54–1.17, p = 0.25); and the number of recurrence during follow-up (OR = 1.12, 95% CI = 0.84–1.50, p = 0.43) suggested that two methods of postoperative perfusion had no significant differences. In terms of safety, including macrohematuria, frequency of urination and bladder irritation symptoms, continuous saline bladder irrigation showed better tolerance than intravesical chemotherapy.


Continuous saline bladder irrigation seems to provide a better balance between prevention of recurrence and local toxicities than intravesical chemotherapy after transurethral resection of bladder tumors.


Non-muscle invasive bladder cancer Meta-analysis Randomized controlled trials Continuous saline bladder irrigation Transurethral resection of bladder tumors 


Author contributions

DY and YC participated in the design of this study. JW performed the statistical analysis. YL and YL collected important background information. ZZ and SZ drafted the manuscript. ZG conceived this study, participated in the design and helped to draft the manuscript. All authors read and approved the final manuscript.

Funding sources


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval and consent to participate

The authors have no ethical conflicts to disclose.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Zhongbao Zhou
    • 1
    • 2
  • Shikai Zhao
    • 3
  • Youyi Lu
    • 2
  • Jitao Wu
    • 2
  • Yongwei Li
    • 2
  • Zhenli Gao
    • 2
  • Diandong Yang
    • 2
    Email author
  • Yuanshan Cui
    • 2
    Email author
  1. 1.Binzhou Medical UniversityYantaiChina
  2. 2.Department of UrologyThe Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantaiChina
  3. 3.Department of AndrologyThe Liaocheng People’s HospitalLiaochengChina

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