World Journal of Urology

, Volume 37, Issue 1, pp 107–114 | Cite as

Update of the International Consultation on Urological Diseases on bladder cancer 2018: non-urothelial cancers of the urinary bladder

  • Shaheen AlaneeEmail author
  • Isabel Alvarado-Cabrero
  • Paari Murugan
  • Rajeev Kumar
  • Kenneth G. Nepple
  • Gladell P. Paner
  • Manish I. Patel
  • Maria Rosaria Raspollini
  • Antonio Lopez-Beltran
  • Badrinath R. Konety
Topic Paper



To provide a comprehensive update of the joint consultation of the International Consultation on Urological Diseases (ICUD) for the diagnosis and management of non-urothelial cancer of the urinary bladder.


A detailed analysis of the literature was conducted reporting on the epidemiology, etiology, diagnosis, treatment and outcomes of non-urothelial cancer of the urinary bladder. An international, multidisciplinary expert committee evaluated and graded the evidence according to the Oxford System of Evidence-based Medicine modified by the ICUD.


The major non-urothelial cancers of the urinary bladder are squamous cell carcinoma, adenocarcinoma, and neuroendocrine tumors. Several other non-urothelial tumors are rare but important to identify because of their aggressive behavior when compared to urothelial bladder tumors. Radical cystectomy and urinary diversion, preceded by neoadjuvant radiation or chemotherapy in some of these tumors, is the main method or treatment for resectable disease. Adjuvant therapy is not usually successful and no novel targeted or immunotherapeutic agents have been identified to provide benefit. Patients with small cell neuroendocrine tumors of the bladder should be offered chemotherapy before surgery. Because non-urothelial cancers are usually locally advanced and/or metastatic at the time of diagnosis, 5-year survival is generally poor.


Non-urothelial cancers of the urinary bladder are rare and mostly lack established protocols for treatment. The prognosis of most of these tumors is poor because they are usually advanced at the time of diagnosis. A multimodal treatment approach should be considered to improve outcomes.


Bladder cancer Non-urothelial ICUD Update 


Author contributions

SA: Data collection, manuscript writing. IA-C: Data collection, manuscript writing. PM: Data collection, manuscript writing. RK: Data collection, manuscript writing. KGN: Data collection, manuscript writing. GPP: Data collection, manuscript writing. MIP: Data collection, manuscript writing. MRR: Data collection, manuscript writing. AL-B: Project supervision, manuscript writing and editing. BRK: Project supervision, manuscript writing and editing.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to disclose.

Ethical statement

I testify on behalf of all co-authors that our article submitted to World Journal of Urology has not been published in whole or in part elsewhere, is not currently being considered for publication in another journal, and that all authors have been personally and actively involved in substantive work leading to the manuscript, and will hold themselves jointly and individually responsible for its content.

Human or animal statement

This research does not involve human or animal subjects. This work is a review of the literature. No institutional review board was required because no active research was preformed.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Shaheen Alanee
    • 1
    Email author
  • Isabel Alvarado-Cabrero
    • 2
  • Paari Murugan
    • 3
  • Rajeev Kumar
    • 4
  • Kenneth G. Nepple
    • 5
  • Gladell P. Paner
    • 6
  • Manish I. Patel
    • 7
  • Maria Rosaria Raspollini
    • 8
  • Antonio Lopez-Beltran
    • 9
  • Badrinath R. Konety
    • 10
  1. 1.Urologic Oncology, Department of UrologyVattikuti Urology Institute, Henry Ford Health SystemDetroitUSA
  2. 2.Department of PathologyMexican Oncology Hospital, IMSS, CMN SXXIMexico CityMexico
  3. 3.Department of Laboratory Medicine and PathologyUniversity of MinnesotaMinneapolisUSA
  4. 4.All India Institute of Medical SciencesNew DelhiIndia
  5. 5.Department of UrologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA
  6. 6.Departments of Pathology and Surgery (Urology)University of ChicagoChicagoUSA
  7. 7.Department of Urology, Westmead Hospital and Discipline of SurgeryUniversity of SydneySydneyAustralia
  8. 8.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  9. 9.University of CordobaCórdobaSpain
  10. 10.Department of Urologic SurgeryUniversity of MinnesotaMinneapolisUSA

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