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World Journal of Urology

, Volume 37, Issue 4, pp 701–708 | Cite as

Predictive and prognostic effect of inflammatory lymphadenopathies in renal cell carcinoma

  • Fabio Muttin
  • Angela Pecoraro
  • Alessandro Larcher
  • Paolo Dell’Oglio
  • Alessandro Nini
  • Francesco Cianflone
  • Francesco Trevisani
  • Federico Dehò
  • Alberto Briganti
  • Andrea Salonia
  • Francesco Montorsi
  • Roberto Bertini
  • Umberto CapitanioEmail author
Original Article

Abstract

Purpose

A significant proportion of patients affected by renal cell carcinoma (RCC) shows a suspicious lymph node involvement (LNI) at preoperative imaging. We sought to evaluate the effect of lymphadenopathies (cN1) on survival in surgical RCC patients with no evidence of LNI at final pathology (pN0).

Methods

719 patients underwent either radical or partial nephrectomy and lymph node dissection at a single tertiary care referral centre between 1987 and 2015. All patients had pathologically no LNI (pN0). Outcomes of the study were cancer-specific mortality (CSM) and other-cause mortality. Multivariable competing-risks regression models assessed the impact of inflammatory lymphadenopathies (cN1pN0) on mortality rates, after adjustment for clinical and pathological confounders.

Results

114 (16%) and 605 (84%) patients (16%) were cN1pN0 and cN0pN0, respectively. cN1pN0 patients were more frequently diagnosed with larger tumours (8.4 vs. 6.5 cm), higher pathological tumour stage (pT3–4 in 71 vs. 36%), higher Fuhrman grade (G3–G4 in 64 vs. 31%), more frequently with necrosis (75 vs. 44%), and distant metastases (33 vs. 10%) (all p < 0.0001). At univariable analysis, inflammatory lymphadenopathies resulted associated with worse CSM (HR 2.45; p < 0.0001). However, at multivariable analysis, inflammatory lymphadenopathies were not an independent predictor of CSM (HR 0.81; p = 0.4). The presence of metastases at diagnosis was the most important factor affecting CSM (HR 6.54; p < 0.0001). This study is limited by its retrospective nature.

Conclusions

In RCC patients, inflammatory lymphadenopathies (cN1pN0) are associated with unfavourable clinical and pathological characteristics. However, the presence of inflammatory lymphadenopathies does not affect RCC-specific mortality.

Keywords

Renal cell carcinoma Lymphadenopathy Lymph node invasion Lymphadenectomy Lymph node dissection 

Notes

Authors’ contributions

RB: supervision and critical revision for important intellectual content. AB: supervision and critical revision for important intellectual content. UC: project development, data collection, data analysis, manuscript editing, supervision, and critical revision for important intellectual content. FC: data collection. FD: data collection. PD: data collection and manuscript editing. Alessandro Larcher: project development, data analysis, and manuscript editing. FM: supervision and critical revision for important intellectual content. FM: data collection, manuscript writing, and manuscript editing. AN: data collection. AP: data collection and manuscript writing. AS: supervision and critical revision for important intellectual content. FT: data collection

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

345_2018_2412_MOESM1_ESM.docx (113 kb)
Supplementary material 1 (DOCX 113 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Fabio Muttin
    • 1
  • Angela Pecoraro
    • 1
  • Alessandro Larcher
    • 1
  • Paolo Dell’Oglio
    • 1
  • Alessandro Nini
    • 1
  • Francesco Cianflone
    • 1
  • Francesco Trevisani
    • 1
  • Federico Dehò
    • 1
  • Alberto Briganti
    • 1
  • Andrea Salonia
    • 1
  • Francesco Montorsi
    • 1
  • Roberto Bertini
    • 1
  • Umberto Capitanio
    • 1
    Email author
  1. 1.Unit of Urology, Division of Experimental Oncology, URI - Urological Research Institute, IRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilanItaly

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