Applied Physics A

, 125:821 | Cite as

ZnO nanorods-gold nanoparticle-based biosensor for detecting hepatitis C

  • Glenda BiasottoEmail author
  • João Paulo C. Costa
  • Paulo I. Costa
  • Maria A. Zaghete


ZnO nanorods comprised of biosensors with Au nanoparticles are described in this study for detecting Hepatitis C virus (HCV). The biosensor device was constructed on a glass substrate with silver and gold electrodes. The ZnO nanorods were grown by microwave hydrothermal synthesis, and the Au nanoparticles were deposited by the sputtering method. The Au nanoparticles were deposited because of the right efficient of anti-HCV antibodies with cystamine and glutaraldehyde. The ZnO nanorods were evaluated using SEM images. The electrochemical biosensor shows a sensitive response to HCV with a detection limit of 0.25 μg/μL. The proposed sensor characteristics of high specificity, good reproducibility and remarkable stability will provide a sensitive, selective, and convenient approach for the detection of HCV.



The financial support for this research project granted by the Brazilian research funding agencies FAPESP (2011/19561–7, 2013/07296–2) is gratefully acknowledged.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.LIEC, Institute of ChemistrySão Paulo State University-UNESPAraraquaraBrazil
  2. 2.School of Pharmaceutical SciencesSão Paulo State University-UNESPAraraquaraBrazil

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