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Mammalian Genome

, Volume 19, Issue 6, pp 379–381 | Cite as

The Collaborative Cross, developing a resource for mammalian systems genetics: A status report of the Wellcome Trust cohort

  • Fuad A. Iraqi
  • Gary Churchill
  • Richard Mott
Article

Abstract

We report on the progress of a project funded by the Wellcome Trust to produce over 100 recombinant inbred mouse lines as part of the Collaborative Cross (CC) genetic reference panel. These new strains of mice are being derived from a set of eight genetically diverse founders. The genomes of the finished strains will be mosaics of the founder strains’ genomes with a high density of independent recombination breakpoints. The CC mice will be available for distribution free of any intellectual property constraints to serve as a community resource for systems genetics studies.

Keywords

Quantitative Trait Locus Litter Size Quantitative Trait Locus Mapping Coat Color Collaborative Cross 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors appreciate the generous support of Wellcome Trust for funding this project, and the International Livestock Research Institute (ILRI) and Tel Aviv University for their technical support.

References

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Department of Human Microbiology, Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  2. 2.The Jackson LaboratoryBar HarborUSA
  3. 3.Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK

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