Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation



To develop a radiomics-based model to stratify the risk of early progression (local/regional recurrence or metastasis) among patients with hypopharyngeal cancer undergoing chemoradiotherapy and modify their pretreatment plans.

Materials and methods

We randomly assigned 113 patients into two cohorts: training (n = 80) and validation (n = 33). The radiomic significant features were selected in the training cohort using least absolute shrinkage and selection operator and Akaike information criterion methods, and they were used to build the radiomic model. The concordance index (C-index) was applied to evaluate the model’s prognostic performance. A Kaplan–Meier analysis and the log-rank test were used to assess risk stratification ability of models in predicting progression. A nomogram was plotted to predict individual risk of progression.


Composed of four significant features, the radiomic model showed good performance in stratifying patients into high- and low-risk groups of progression in both the training and validation cohorts (log-rank test, p = 0.00016, p = 0.0063, respectively). Peripheral invasion and metastasis were selected as significant clinical variables. The combined radiomic–clinical model showed good discriminative performance, with C-indices 0.804 (95% confidence interval (CI), 0.688–0.920) and 0.756 (95% CI, 0.605–0.907) in the training and validation cohorts, respectively. The median progression-free survival (PFS) in the high-risk group was significantly shorter than that in the low-risk group in the training (median PFS, 9.5 m and 19.0 m, respectively; p [log-rank] < 0.0001) and validation (median PFS, 11.3 m and 22.5 m, respectively; p [log-rank] = 0.0063) cohorts.


A radiomics-based model was established to predict the risk of progression in hypopharyngeal cancer with chemoradiotherapy.

Key Points

Clinical information showed limited performance in stratifying the risk of progression among patients with hypopharyngeal cancer.

Imaging features extracted from CECT and NCCT images were independent predictors of PFS.

We combined significant features and valuable clinical variables to establish a nomogram to predict individual risk of progression.

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Contrast-enhanced computed tomography


Dynamic contrast-enhanced magnetic resonance imaging


Head and neck squamous cell carcinoma


Intra-/inter-class correlation coefficient


Non-contrast computed tomography


Positron emission tomography–computed tomography


Progression-free survival


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This work is supported by the National Natural Science Foundation of China (81571664, 81871323, 81801665, 81227901, 81771924, 81501616, 81671854), the National Natural Science Foundation of Guangdong Province (2018B030311024), the Scientific Research General Project of Guangzhou Science Technology and Innovation Commission (201707010328), the China Postdoctoral Science Foundation (2016 M600145), and the Beijing Natural Science Foundation (L182061).


This study has received funding by the National Natural Science Foundation of China (81571664, 81871323, 81801665, 81227901, 81771924, 81501616, 81671854), the National Natural Science Foundation of Guangdong Province (2018B030311024), the Scientific Research General Project of Guangzhou Science Technology and Innovation Commission (201707010328), the China Postdoctoral Science Foundation (2016 M600145), and the Beijing Natural Science Foundation (L182061).

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Correspondence to Jie Tian or Shuixing Zhang.

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The scientific guarantor of this publication is Shuixing Zhang.

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The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

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Mo, X., Wu, X., Dong, D. et al. Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation. Eur Radiol 30, 833–843 (2020).

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  • Head and neck cancer
  • Hypopharynx
  • Chemoradiotherapy
  • Recurrence
  • Prognosis