Role of one-pass breast lesion excision system in complete excision of high-risk breast lesions with atypia expressed as clusters of microcalcifications
- 33 Downloads
To assess the role of the breast lesion excision system (BLES) in complete removal of clusters of microcalcifications found on mammogram proved histologically to be high-risk lesions with cell atypia.
Methods and materials
Three hundred ninety-four consecutive women (mean age 58.5 years, range 39–78 years) with 400 clusters of suspicious microcalcifications underwent stereotactic biopsy using the intact BLES device between January 2014 and January 2016. All cases proved histologically to be high-risk lesions were subsequently assessed for complete removal. The underestimation rate was also assessed.
Thirty-eight out of 400 (9.5%) lesions were high-risk lesions with atypia with mean size 7.63 mm (st. dev. = 4.03 mm) which was within the size that the BLES needle can excise (20 mm). Four (10.5%) papillomas with atypia, 14 (36.8%) cases with flat epithelial atypia (FEA), 10 (26.3%) cases with lobular intraepithelial neoplasia (LIN-LIN 1, LIN 2), 8 (21.2%) with atypical ductal hyperplasia (ADH) and 2 (5.3%) cases with mucocele-like lesions (MLL) with atypia were found. Twenty-nine out of 38 lesions had subsequent surgery. Complete excision was achieved in 23/29 lesions (79.3%). No underestimation was found. Two-year mammographic stability was found in all lesions. Non-parametric statistical analysis showed no other significant predictive factor for complete excision apart from the distance of the lesions from the specimen margins (p = 0.031 Mann-Whitney test).
One-pass BLES intact biopsy technique is a safe method of complete removal of high-risk atypical lesions with high accuracy rates for certain histologies and could be potentially used as an alternative excision method to diagnostic surgery in selected cases.
• Breast lesion excision system (BLES) is an image-guided biopsy technique that uses radiofrequency to remove an intact piece of tissue including the target breast neoplasm.
• Breast lesion excision system (BLES) under stereotactic guidance is able to accurately biopsy high-risk breast lesions expressed mammographically as clusters of suspicious microcalcifications.
• BLES under stereotactic guidance is an accurate technique for en bloc excision of selected cases of small clusters of suspicious microcalcifications proved to be high-risk lesions with histopathologically disease-free margins of excision.
KeywordsBreast neoplasms Image-guided biopsy Margins of excision
Atypical ductal hyperplasia
Area under the curve
Breast Imaging Reporting and Data System
Breast lesion excision system
Ductal carcinoma in situ
Flat epithelial atypia
Lobular intraepithelial neoplasia
- LIN 1
Lobular intraepithelial neoplasia type 1
- LIN 2
Lobular intraepithelial neoplasia type 2
Magnetic resonance imaging
Receiver operating characteristic
- st. dev.
The authors state that this work has not received any funding.
Compliance with ethical standards
The scientific guarantor of this publication is George C Zografos, Professor of Surgery Hippokration Hospital, School of Medicine, National and Kapodistrian University of Athens firstname.lastname@example.org.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
Statistics and biometry
Georgios Dimakopoulos kindly provided statistical advice for this manuscript.
Written informed consent was obtained from all subjects (patients) in this study.
Institutional Review Board approval was obtained.
• diagnostic or prognostic study
• performed at one institution
- 1.Adams AL (2010) Flat epithelial atypia: a review of current concepts. Open Breast Cancer J 2:90–94Google Scholar
- 4.Leibman AJ, Staeger CN, Charney DA (2006) Mucocelelike lesions of the breast: mammographic findings with pathologic correlation. AJR Am J Roentgenol 186:1356–1360Google Scholar
- 16.Lipman M, Chambers A, Umphrey HR (2018) Current management of high-risk breast lesions. Curr Radiol Rep 6:7. https://doi.org/10.1007/s40134-018-0268-6
- 33.Londero V, Zuiani C, Linda A, Girometti R, Bazzocchi M, Sardanelli F (2012) High-risk breast lesions at imaging-guided needle biopsy: usefulness of MRI for treatment decision. AJR Am J Roentgenol 199:240–W250Google Scholar