Speed of sound ultrasound: a pilot study on a novel technique to identify sarcopenia in seniors
To measure speed of sound (SoS) with a novel hand-held ultrasound technique as a quantitative indicator for muscle loss and fatty muscular degeneration.
Both calf muscles of 11 healthy, young females (mean age 29 years), and 10 elderly females (mean age 82 years) were prospectively examined with a standard ultrasound machine. A flat Plexiglas® reflector, on the opposite side of the probe with the calf in between, was used as timing reference for SoS (m/s) and ΔSoS (variation of SoS, m/s). Handgrip strength (kPA), Tegner activity scores, and 5-point comfort score (1 = comfortable to 5 = never again) were also assessed. Ultrasound parameters (muscle/adipose thickness, echo intensity) were measured for comparison.
Both calves were assessed in less than two minutes. All measurements were successful. The elderly females showed significantly lower SoS (1516 m/s, SD17) compared to the young adults (1545 m/s, SD10; p < 0.01). The ΔSoS of elderly females was significantly higher (12.2 m/s, SD3.6) than for young females (6.4 m/s, SD1.5; p < 0.01). Significant correlations of SoS with hand grip strength (r = 0.644) and Tegner activity score (rs = 0.709) were found, of similar magnitude as the correlation of hand grip strength with Tegner activity score (rs = 0.794). The average comfort score of the elderly was 1.1 and for the young adults 1.4. SoS senior/young classification (AUC = 0.936) was superior to conventional US parameters.
There were significant differences of SoS and ΔSoS between young and elderly females. Measurements were fast and well tolerated. The novel technique shows potential for sarcopenia quantification using a standard ultrasound machine.
• Speed of sound ultrasound: a novel technique to identify sarcopenia in seniors.
• Measurements were fast and well tolerated using a standard ultrasound machine.
• The novel technique shows potential for sarcopenia quantification.
KeywordsSkeletal muscle Ultrasonography Aging Sarcopenia Adipose tissue
American College of Radiology
Area under curve
Body mass index
Magnetic resonance imaging
Receiver operating characteristic
Speed of sound
This study has received funding by USZ Foundation and an ETH Zurich & ETH Zurich Foundation Pioneer Fellowship. This project has been generously supported by a donation from Dr. Hans-Peter Wild to the USZ Foundation.
Compliance with ethical standards
The scientific guarantor of this publication is Marga Rominger.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
No complex statistical methods were necessary for this paper.
Written informed consent was obtained from all subjects (patients) in this study.
Institutional Review Board approval was obtained.
• Case-control study
• Performed at one institution
- 21.Sanabria SJ, Goksel O (2016) Hand-held sound-speed mammography based on ultrasound reflector tracking. In: Ourselin S et al (eds) Medical Image Computing and Computer-Assisted Intervention - MICCAI 2016, Part I, LNCS, 9900, 567–576Google Scholar
- 22.Sanabria SJ, Goksel O (2016) Hand-held medical ultrasound apparatus and system for determining a tomographic image. PCT/EP2016/070321 (patent pending)Google Scholar
- 24.Szabo T (2004) Diagnostic ultrasound imaging: inside out, 1st edn. Academic Press, BurlingtonGoogle Scholar
- 27.Fortbildungen für orthopädische Medizin und manuelle Therapie (FOMT) Report (2013) TAS − Tegner activity scale. https://www.fomt.info/Frageboegen/TAS-Tegner-acitivity-scale-deutsche-Version.pdf
- 29.Stewart A (2010) Basic statistics and epidemiology: a practical guide, 3rd edn. Radcliffe Pub, AbingdonGoogle Scholar
- 46.da Silva Pereira Júnior N, da Matta TT, Alvarenga AV, de Albuquerque Pereira WC, de Oliveira LF (2017) Reliability of ultrasound texture measures of biceps brachialis and gastrocnemius Lateralis muscles’ images. Clin Physiol Funct Imaging 37:84–88Google Scholar
- 54.Topp KA, O’Brien WD (1998) Anisotropy of ultrasonic parameters in fresh rat skeletal muscle in vitro. In: Schneider SC, Levy M, McAvoy BR (eds) IEEE Ultrasonics Symposium, Sendai, Japan, pp 1369–1372Google Scholar
- 56.Qu X, Azuma T, Lin H et al (2017) Limb muscle sound speed estimation by ultrasound computed tomography excluding receivers in bone shadow. In: N Duric, B Heyde (eds) Proceedings of the SPIE, Volume 10139, id. 101391B 8 ppGoogle Scholar