Short term comparison between blind and ultrasound guided injection in morton neuroma
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The aim of this work is to compare the effectiveness of blind and ultrasound-guided injection for Morton’s neuroma (MN) to determine which is more appropriate as the initial procedure in conservative treatment.
This is an evaluator-blinded randomised trial. Of the 56 included patients, 27 were assigned to the blind group (A) and 29 to the ultrasound-guided group (B). Injection includes 1 ml of 2% mepivacaine and 40 mg of triamcinolone in each web space with MN. The included patients were assessed clinically by VAS score and the Manchester Foot Pain and Disability Score (MFPDS). The follow-up was performed at 15 days, 1 month, 45 days, 2 months, 3 months and 6 months after the initial injection.
No differences in age or clinical measurements were found at presentation between group A and group B. At the follow-up, the ultrasound-guided group showed greater symptomatic relief at several stages of the follow-up: 45 days (VAS 3.0 ± 0.5 versus 5.5 ± 0.5, p = 0.001; MFPDS: 32.2 ± 1.8 versus 38.8 ± 2.0, p = 0.018), 2 months (VAS: 3.1 ± 0.5 versus 5.6 ± 0.5, p = 0.002; MFPDS: 31.5 ± 1.9 versus 38.5 ± 2.1, p = 0.020) and 3 months (VAS: 3.1 ± 0.4 versus 5.2 ± 0.6, p = 0.010; MFPDS: 31.2 ± 1.9 versus 37.7 ± 2.4, p = 0.047).
Injection of MN under ultrasound guidance provides a statistically significant improvement at some stages of the follow-up (45 days, 2 and 3 months), compared with blind injection.
• Ultrasound-guided steroid injections in Morton’s neuroma provide short-term pain relief to over 60% of the patients.
• Ultrasound-guided injections in Morton’s neuroma lead to a higher percentage of short-term pain relief than blind injections.
• Ultrasound-guided injections in Morton’s neuroma lead to a lower percentage of skin side effects than blind injections.
KeywordsMorton neuroma Ultrasonography interventional Metatarsalgia
Manchester Foot Pain and Disability Score
Visual analogue scale
Thanks to Loreto Vasquez for her kind collaboration reviewing the English grammar of the article and to Manuela Exposito Ruiz for her statistical support.
The authors state that this work has not received any funding.
Compliance with ethical standards
The scientific guarantor of this publication is Fernando Ruiz Santiago
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
Manuela Exposito Ruiz, from FIBAO, Hospital Virgen de las Nieves, kindly provided statistical advice for this manuscript.
One of the authors has significant statistical expertise.
Written informed consent was obtained from all subjects (patients) in this study.
Institutional Review Board approval was obtained.
• randomised controlled trial
• performed at one institution
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