LI-RADS v2017 categorisation of HCC using CT: Does moderate to severe fatty liver affect accuracy?
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To compare the sensitivity of Liver Imaging Reporting and Data System (LI-RADS) v2017 for diagnosis of hepatocellular carcinoma (HCC) using multiphasic computed tomography (CT) between patients with and without moderate to severe fatty liver (MSFL).
This retrospective study included a total of 106 high-risk patients with 112 pathologically proven HCCs who underwent multiphasic CT. Patients were classified as MSFL (24 men, 2 women; mean age, 59.5 years [range, 38–79 years]) and non-MSFL (64 men, 16 women; mean age, 62.9 years [range, 40–89 years]) groups according to unenhanced CT liver and spleen parenchymal attenuation. Two independent radiologists assigned LI-RADS categories and accessed HCC features on CT. Sensitivities for LR-5 assignment and frequencies of HCC features were compared between the two groups.
Sensitivities of LR-5 assignment for diagnosing HCCs were not significantly different between MSFL and non-MSFL groups (65.4% [17/26] vs. 76.7% [66/86] for reviewer 1, p = 0.247; 73.1% [19/26] vs. 76.74% [66/86] for reviewer 2, p = 0.702). No significant differences in the frequencies of arterial hyperenhancement, washout, and capsule were observed between the two groups (96.2% [25/26] vs. 98.8% [85/86], p = 0.412; 80.8% [21/26] vs. 89.5% [77/86], p = 0.308; and 53.8% [14/26] vs. 57% [49/86], p = 0.778, respectively).
LI-RADS v2017 using CT showed comparable sensitivity for diagnosing HCC regardless of MSFL.
• Using LI-RADS v2017 with CT, diagnosis of HCC in patients with MSFL showed similar sensitivity to that in patients without MSFL.
• Frequencies of major HCC features (arterial hyperenhancement, washout, and capsule) on CT between the MSFL and non-MSFL groups were not significantly different.
• LI-RADS using CT may be feasible for diagnosing HCC in patients with fatty liver.
KeywordsCarcinoma, hepatocellular Fatty liver Multidetector computed tomography Liver neoplasms
Intraclass correlation coefficient
Liver Imaging Reporting and Data System
Moderate to severe fatty liver
Non-alcoholic fatty liver disease
Region of interest
Tumour in vein
This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.
This work was supported by the Soonchunhyang University Research Fund.
Compliance with ethical standards
The specific guarantor of this publication is Sung Shick Jou, the head of the Radiology Department of Soonchunhyang University College of Medicine, Cheonan Hospital, Republic of Korea
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
Suyeon Park and Nam Hun Heo kindly provided statistical advice for this manuscript.
Written informed consent was waived by the Institutional Review Board because of the retrospective nature of the study.
Institutional Review Board approval was obtained.
Retrospective, observational, performed at one institution