Microvascular perfusion in infarcted and remote myocardium after successful primary PCI: angiographic and CMR findings
The aim of this study was to investigate the association between TIMI myocardial perfusion (TMP) grading acute and cardiac magnetic resonance (CMR) first-pass perfusion early and at 4 months in patients with ST-segment-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI).
Material and methods
One hundred ninety-eight STEMI patients were recruited from the POSTEMI study. TMP grade was assessed after PCI; CMR was performed at day 2 and after 4 months. Signal intensity was measured on first-pass perfusion images, and a maximum contrast enhancement index (MCE) was calculated.
Patients with TMP grade 2-3 (n = 108) after PCI had significantly better EF (59 ± 10 vs. 51 ± 13, p < 0.001) and smaller infarct volume (12 ± 8 vs. 19 ± 12 %, p < 0.001) at 4 months compared with patients with TMP grade 0-1 (n = 81). MCE in the infarcted (MCEi) and remote myocardium (MCEr) improved from early to follow-up CMR, MCEi from 94 ± 56 to 126 ± 59, p < 0.001, and MCEr from 112 ± 51 to 127 ± 50, p < 0.001. In patients with the lowest CMR perfusion early, perfusion at 4 months remained decreased compared with the other groups, MCEi 108 ± 75 vs. 133 ± 51, p = 0.01, and MCEr 115 ± 41 vs. 131 ± 52, p = 0.047.
TMP grade and early CMR first-pass perfusion were associated with CMR outcomes at 4 months. First-pass perfusion improved after 4 months in the infarcted and remote myocardium. However, in patients with the lowest CMR perfusion early, perfusion was still reduced after 4 months.
• Cardiac magnetic resonance myocardial first-pass perfusion and TMP grading after successful PCI helps to assess risk in patients with ST elevation myocardial infarction.
• Cardiac magnetic resonance myocardial first-pass perfusion shows that microvascular perfusion after ST elevation myocardial infarction can be impaired in both infarcted and non-infarcted myocardium.
• Microvascular perfusion improves over time in patients with ST elevation myocardial infarction treated with primary PCI.
KeywordsST elevation myocardial infarction Magnetic resonance imaging Myocardial reperfusion Percutaneous coronary intervention
Area at risk
Cardiac magnetic resonance
Infarct related artery
Late gadolinium enhancement
Myocardial “blush” grade
Maximum contrast enhancement index
MCE in the infarcted myocardium
MCE in the remote myocardium
Percutaneous coronary intervention
Postconditioning in STEMI study
Thrombolysis in myocardial infarction
TIMI myocardial perfusion
Time to peak contrast enhancement
The authors thank the radiographers and staff of the Department of Cardiology and Radiology at the Oslo University Hospital, Ullevål.
The authors state that this work has not received any funding.
Compliance with ethical standards
The scientific guarantor of this publication is Pavel Hoffmann.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
One of the authors, David Swanson, has significant statistical expertise.
Written informed consent was obtained from all subjects (patients) in this study.
Institutional Review Board approval was obtained.
Study subjects or cohorts overlap
Several articles on the cohort of patients included in the POSTEMI trial have been published [1-5]. The results reported were mainly clinical and biochemical endpoints. CMR results reported were infarct size, left ventricular function, microvascular obstruction, area at risk and myocardial salvage. Data on CMR first-pass perfusion have not been published yet.
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• randomized controlled trial
• performed at one institution
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