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European Radiology

, Volume 29, Issue 1, pp 115–123 | Cite as

Abnormal corpus callosum induced by diabetes impairs sensorimotor connectivity in patients after acute stroke

  • Xinfeng Yu
  • Yeerfan Jiaerken
  • Xiaojun Xu
  • Alan Jackson
  • Peiyu Huang
  • Linglin Yang
  • Lixia Yuan
  • Min Lou
  • Quan Jiang
  • Minming Zhang
Neuro
  • 131 Downloads

Abstract

Objectives

To test the hypothesis that abnormal corpus callosum (CC) induced by diabetes may impair inter-hemispheric sensorimotor functional connectivity (FC) that is associated with poor clinical outcome after stroke.

Methods

Forty-five patients with acute ischaemic stroke in the middle cerebral artery territory and 14 normal controls participated in the study. CC was divided into five subregions on three-dimensional T1-weighted image. The microstructural integrity of each subregion of CC was analysed by DTI and the inter-hemispheric FCs in primary motor cortex (M1-M1 FC) and primary sensory cortex (S1-S1 FC) were examined by resting-state functional magnetic resonance imaging.

Results

Diabetic patients (n = 26) had significantly lower fractional anisotropy (FA) in the isthmus of CC (CCisthmus) when compared with non-diabetic patients (n = 19) and normal controls (p < 0.0001). In addition, diabetic patients had the lowest M1-M1 FC (p = 0.015) and S1-S1 FC (p = 0.001). In diabetic patients, reduced FA of CCisthmus correlated with decreased M1-M1 FC (r = 0.549, p = 0.004) and S1-S1 FC (r = 0.507, p = 0.008). Decreased M1-M1 FC was independently associated with poor outcome after stroke in patients with diabetes (odds ratio = 0.448, p = 0.017).

Conclusions

CC degeneration induced by diabetes impairs sensorimotor connectivity and dysfunction of motor connectivity can contribute to poor recovery after stroke in patients with diabetes.

Key points

• Abnormal isthmus of corpus callosum in stroke patients with diabetes.

• Abnormal isthmus of corpus callosum correlated with decreased inter-hemispheric sensorimotor connectivity.

• Decreased motor connectivity correlated with poor stroke outcome in diabetic patients.

Keywords

Stroke Diabetes mellitus White matter Cerebral cortex Magnetic resonance imaging 

Abbreviations

CC

Corpus callosum

CST

Corticospinal tract

FA

Fractional anisotropy

FC

Functional connectivity

FPG

Fasting plasma glucose

M1

Primary motor cortex

MD

Mean diffusivity

NC

Normal controls

NIHSS

National Institute of Health Stroke Score

S1

Primary sensory cortex

WMH

White matter hyperintensities

Notes

Funding

This study has received funding by the National Natural Science Foundation of China (No. 81271530), the Zhejiang Provincial Natural Science Foundation of China (No. LQ17H180002 & LZ14H180001), and the Medical and Health Science and Technology Project of Zhejiang Province (No. 2017KY377)

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Minming Zhang.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• prospective

• cross-sectional study

• performed at one institution

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  1. 1.Department of Radiology, The 2nd Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina
  2. 2.Wolfson Molecular Imaging CentreUniversity of ManchesterManchesterUK
  3. 3.Department of Psychiatry, The 2nd Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina
  4. 4.Department of Biomedical Engineering and Instrument Science, Key Laboratory for Biomedical Engineering of Education Ministry of ChinaZhejiang UniversityHangzhouChina
  5. 5.Department of Neurology, The 2nd Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina
  6. 6.Department of NeurologyHenry Ford Health SystemDetroitUSA

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