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European Radiology

, Volume 28, Issue 11, pp 4909–4918 | Cite as

The role of core needle biopsy in the diagnosis of initially detected thyroid nodules: a systematic review and meta-analysis

  • Sae Rom Chung
  • Chong Hyun Suh
  • Jung Hwan Baek
  • Young Jun Choi
  • Jeong Hyun Lee
Head and Neck
  • 256 Downloads

Abstract

Objectives

To systematically review the published literature and evaluate the efficacy and safety of core needle biopsy (CNB) for initially detected thyroid nodules.

Methods

The Ovid-MEDLINE and Embase databases were searched for studies evaluating CNB for the diagnosis of initially detected thyroid nodules. A meta-analysis was performed to evaluate non-diagnostic results, inconclusive results and diagnostic accuracy for a diagnosis of malignancy with CNB. To overcome heterogeneity, multiple subgroup analyses were performed. The complication rate was also evaluated.

Results

Thirteen eligible studies, which included a total sample size of 9,166 patients with 13,585 nodules, were included. The pooled proportions were 3.5% (95% CI 2.4–5.1) for non-diagnostic results and 13.8% (95% CI 9.1–20.3) for inconclusive results. Considerable heterogeneity was observed among the studies in terms of the pooled proportions for CNB (I2=92.9%, 97%). With regard to the diagnostic performance for malignancy, the sensitivity was 80% (95% CI 75–85) and the specificity was 100% (95% CI 93–100). Only two major complications of CNB were observed.

Conclusions

CNB demonstrates a low non-diagnostic result rate and high diagnostic accuracy for initially detected thyroid nodules and a low major complication rate. These findings indicate that CNB may be a feasible diagnostic tool for patients with initially detected thyroid nodules.

Key Points

  • CNB demonstrates high diagnostic accuracy for initially detected thyroid nodules.

  • CNB demonstrates a low major complication rate.

  • CNB may be a feasible diagnostic tool for patients with initially detected thyroid nodules.

Keywords

Thyroid neoplasms Biopsy, large-core needle Biopsy, fine-needle Ultrasonography 

Abbreviations

AUS

Atypia of undetermined significance

CNB

Core needle biopsy

FNA

Fine needle aspiration

US

Ultrasound

Notes

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Jung Hwan Baek.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

Informed consent

Written informed consent was not required for this study because it is systematic review and meta-analysis.

Ethical approval

Institutional Review Board approval was not required because it is systematic review and meta-analysis.

Methodologys

• Meta-analysis

Supplementary material

330_2018_5494_MOESM1_ESM.docx (2.2 mb)
ESM 1 (DOCX 2250 kb)

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  • Sae Rom Chung
    • 1
  • Chong Hyun Suh
    • 2
  • Jung Hwan Baek
    • 1
  • Young Jun Choi
    • 1
  • Jeong Hyun Lee
    • 1
  1. 1.Department of Radiology and Research Institute of RadiologyUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulRepublic of Korea
  2. 2.Department of RadiologyNamwon Medical CenterNamwon-siRepublic of Korea

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