Meniscal pathologies on MRI correlate with increased bone tracer uptake in SPECT/CT
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To assess the relationship of subchondral bone tracer uptake (BTU) on SPECT/CT and meniscal pathologies on MRI in patients with painful knees.
Twenty-five patients who had MRI and SPECT/CT within 3 months without knee surgery or grade ≥3 cartilage lesions were prospectively included. Maximum values of each subchondral femorotibial area were quantified and a ratio was calculated in relation to a femoral shaft reference region, which represented the BTU background activity. Meniscal lesions were graded (intact/degeneration/tear) and meniscal extrusion (no/yes) was assessed using MRI by two musculoskeletal radiologists blinded to the SPECT/CT findings. One-tailed Spearman correlations served for statistics (p < 0.05).
Knees with meniscal degeneration or tear showed a significantly higher BTU in the medial femorotibial compartment (p = 0.045) when compared to intact menisci. Meniscal degeneration was associated with an increased BTU in the lateral femorotibial compartment; however, this was not statistically significant (p = 0.143). Patients with an extruded meniscus showed significantly higher BTU compared to a non-extruded meniscus (p < 0.020).
Medial femorotibial BTU in SPECT/CT was associated with meniscal pathologies. Highest BTU was found in patients with meniscal tears. SPECT/CT appears to be a useful imaging modality to identify patients with overloading or early osteoarthritis.
• Meniscal degeneration and tears correlate significantly with increased BTU using SPECT/CT.
• Medial meniscus extrusion is associated with an increased BTU in SPECT/CT.
• SPECT/CT allows detection of overloading and early osteoarthritis.
KeywordsSingle photon emission computed tomography/computed tomography Meniscus Knee injuries Osteoarthritis Magnetic resonance imaging
Bone tracer uptake
Intraclass correlation coefficient
Single photon emission computerised tomography
Magnetic resonance imaging
The authors state that this work has not received any funding.
Compliance with ethical standards
The scientific guarantor of this publication is Michael Hirschmann.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
Felix Amsler kindly provided statistical advice for this manuscript.
Written informed consent was waived by the Institutional Review Board (EK 228/13).
Institutional Review Board approval was obtained (EK 228/13).
Study subjects or cohorts overlap
Some study subjects or cohorts have been previously reported in Dordevic et al. .
• diagnostic study
• performed at one institution
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