The 3D reconstructions of female pelvic autonomic nerves and their related organs based on MRI: a first step towards neuronavigation during nerve-sparing radical hysterectomy
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To present in vivo female pelvic autonomous innervation and the relationship between nerves and their related organs by three-dimensional (3D) reconstruction based on magnetic resonance imaging (MRI).
Thirty patients with cervical cancer who underwent pelvic MRI and agreed to undergo additional magnetic resonance neurography (MRN) sequences were enrolled in the present study. MRI images from the same patient were acquired using T2-weighted fat saturation (T2W FS) and 3D-STIR-SPACE sequences. Detailed two-dimensional (2D) segmentation and 3D reconstruction of pelvic autonomic nerves (PAN) were performed on the basis of the images of the two sequences using 3D reconstruction software. The 2D segmentation and 3D reconstruction of pelvic organs were based on T2W FS images. The consistency of the 3D models of pelvic autonomous innervation constructed from the two sequences were analysed and compared, the pelvic autonomous innervation was presented, and the relationship between nerves and their related organs was characterised.
The 3D reconstructions of PAN were successfully obtained from 3D-STIR-SPACE and T2W FS sequences in 30 patients and showed high correspondence. T2W FS images also enabled 3D reconstructions of pelvic organs to visualise the 3D distribution of PAN and the positional relationships between nerves and their related organs.
The pelvic autonomic nerves and their related organs can be reconstructed on the basis of MRI to present personalised 3D anatomical information and offer individualised guidance during nerve-sparing radical hysterectomy (NSRH).
• Nerve-sparing radical hysterectomy is a developing trend in cervical cancer surgery
• MRI allows reconstructions of pelvic autonomic nerves and their related organs
• The 3D reconstructions provide detailed 3D anatomical information on nerves
KeywordsThree-dimensional imaging Hypogastric plexus Splanchnic nerves Magnetic resonance imaging Neuronavigation
Inferior hypogastric plexus
Maximum intensity projection
Magnetic resonance imaging
Magnetic resonance neurography
Nerve-sparing radical hysterectomy
Pelvic autonomic nerves
Pelvic splanchnic nerves
Superior hypogastric plexus
- T2W FS
T2-weighted fat saturation
This study has received funding by the National Natural Science Fund of China (81571422), the National Science and Technology Support Program of China (2014BAI05B03), the National Natural Science Fund of Guangdong (2015A030311024) and the Science and Technology Plan of Guangzhou (158100075).
Compliance with ethical standards
The scientific guarantor of this publication is Chunlin Chen.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
Statistics and biometry
No complex statistical methods were necessary for this paper.
Written informed consent was obtained from all subjects (patients) in this study.
Institutional review board approval was obtained.
Study subjects or cohorts overlap
Some study subjects or cohorts have been previously reported in European Radiology.
• performed at one institution