Diagnostic value of six MRI features for central neurocytoma
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To increase our understanding of the imaging features of central neurocytoma (CN) and improve the preoperative MRI diagnosis accuracy.
Preoperative MR images of 30 CNs and another 68 intraventricular non-CN tumours were analysed by one experienced neuroradiologist retrospectively to identify previously reported features and new features of CN. Six blinded radiologists independently reviewed all these MRI images, and scored all characteristic features on a five-point scale. Diagnostic value was assessed by the area under the receiver operating characteristic curve (AUC); sensitivity, specificity and accuracy were also calculated.
In addition to the ‘scalloping’ sign, ‘broad-based attachment’ sign and ‘soap-bubble’ sign, three new MRI features of CN were identified, including the ‘peripheral cysts’ sign, ‘fluid-fluid level’ sign and the ‘gemstone’ sign. The scalloping sign showed the highest AUC value (0.82), followed by the peripheral cysts sign (0.75) and broad-based attachment sign (0.75). The scalloping sign exhibited the highest specificity (82%), followed by the fluid-fluid level sign (79%) and gemstone (78%) sign. The broad-based attachment sign (85%) was the most sensitive feature, followed by the soap-bubble sign (84%) and peripheral cysts sign (77%).
There are six characteristic MRI features that help to improve the preoperative diagnostic accuracy of CN.
• This study is the largest magnetic resonance imaging (MRI) cohort on central neurocytoma (CN).
• Three new features helpful for the diagnosis of CN were reported.
• Diagnostic value of six MRI features of CN was preliminarily determined.
KeywordsCerebral ventricle neoplasms Neurocytoma Magnetic resonance imaging Diagnostic imaging ROC curve
Area under the curve
Receiver operating characteristic
This study has received funding by the Natural Science Foundation of Guangdong Province, China, the Science and Technology Program of Guangzhou, China, and the Special Foundation of President of Nanfang Hospital, Southern Medical University.
Compliance with ethical standards
The scientific guarantor of this publication is Prof. Dr. Yuankui Wu, Department of Medical Imaging, Nanfang Hospital, Southern Medical University.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
Statistics and biometry
No complex statistical methods were necessary for this paper.
Written informed consent was waived by the Institutional Review Board.
Institutional Review Board approval was obtained.
Study subjects or cohorts overlap
MRI data of 12 patients of CN have been previously reported in Journal of Neuro-Oncology.
• diagnostic or prognostic study
• performed at one institution
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