Comparison of T2 Relaxation Values in Subtalar Cartilage between Patients with Lateral Instability of the Ankle Joint and Healthy Volunteers
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To evaluate the difference between T2 relaxation values of the subtalar cartilage in lateral ankle instability patients and healthy volunteers.
Materials and Methods
This institutional review board-approved study included 27 preoperative magnetic resonance imaging (MRI) examinations of 26 patients who underwent Broström operations. Data of previously enrolled healthy volunteers (12 volunteers, 13 MRIs) were used as controls. Two radiologists independently measured T2 values in eight posterior subtalar joint cartilage compartments: central calcaneus anterior (CCA) and posterior (CCP), central talus anterior (CTA) and posterior (CTP), lateral calcaneus anterior (LCA) and posterior (LCP), and lateral talus anterior (LTA) and posterior (LTP). Patient and control values were compared using linear regression analysis. Inter- and intraobserver agreement was calculated.
Mean T2 values were significantly higher in the patient group in all measurements of subtalar joint cartilage compartments (p < 0.05) except that in LTP (p = 0.085) measured by reviewer 1. Both inter- and intraobserver agreements were excellent.
The T2 relaxation values of the subtalar cartilage were significantly higher in lateral ankle instability patients compared with those of controls.
• Subtalar cartilage T2 values are increased in patients with lateral ankle instability.
• This trend was demonstrated regardless of the presence of talar dome cartilage lesions.
• Inter-and intraobserver agreements were excellent (intraclass coefficient range, 0.765-0.951) in subtalar cartilage T2 mapping.
KeywordsT2 relaxation mapping Subtalar joint Lateral instability of the ankle joint
Central calcaneus anterior
Central calcaneus posterior
Central talus anterior
Central talus posterior
Lateral calcaneus anterior
Lateral calcaneus posterior
Lateral talus anterior
Lateral talus posterior
Magnetic resonance imaging
The authors state that this work has not received any funding.
Compliance with ethical standards
The scientific guarantor of this publication is Young Cheol Yoon.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
Min-Ji Kim and Soohyun Ahn kindly provided statistical advice for this manuscript.
Written informed consent was waived by the Institutional Review Board.
Institutional Review Board approval was obtained.
Study subjects or cohorts overlap
Some study subjects or cohorts have been previously reported in the article titled “T2 relaxation values of the talar trochlear articular cartilage: comparison between patients with lateral instability of the ankle joint and healthy volunteers” (American Journal of Roentgenology, January 2016, Volume 206, Number 1). The subjects in this previously published article, 12 patients (13 ankle MRIs) and 12 healthy volunteers (13 ankle MRIs), were all included in the 38 subjects (40 MRIs) of our manuscript. The previously published article focused on T2 relaxation values in talar trochlear cartilage and their potential relation with lateral ankle instability. In the submitted manuscript, we reported our study result on T2 relaxation values in the subtalar joint (both talar and calcaneal articular cartilage), in which the role of compositional quantitative MRI measurement has not been established. Thus, we believe the submitted manuscript is different from the previously published article, which includes some of our study population.
• performed at one institution
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