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European Radiology

, Volume 28, Issue 10, pp 4134–4145 | Cite as

Superolateral Hoffa’s fat pad (SHFP) oedema and patellar cartilage volume loss: quantitative analysis using longitudinal data from the Foundation for the National Institute of Health (FNIH) Osteoarthritis Biomarkers Consortium

  • Arya Haj-Mirzaian
  • Ali Guermazi
  • Nima Hafezi-Nejad
  • Christopher Sereni
  • Michael Hakky
  • David J. Hunter
  • Bashir Zikria
  • Frank W. Roemer
  • Shadpour Demehri
Musculoskeletal
  • 241 Downloads

Abstract

Objectives

To determine the association of superolateral Hoffa’s fat pad (SHFP) oedema and patellofemoral joint structural damage in participants of Foundation for the National Institute of Health Osteoarthritis Biomarkers Consortium study.

Methods

Baseline and 24-month MRIs of 600 subjects were assessed. The presence of SHFP oedema (using 0–3 grading scale) and patellar morphology metrics were determined using baseline MRI. Quantitative patellar cartilage volume and semi-quantitative MRI osteoarthritis knee score (MOAKS) variables were extracted. The associations between SHFP oedema and patellar cartilage damage, bone marrow lesion (BML), osteophyte and morphology were evaluated in cross-sectional model. In longitudinal analysis, the associations between oedema and cartilage volume loss (defined using reliable change index) and MOAKS worsening were evaluated.

Results

In cross-sectional evaluations, the presence of SHFP oedema was associated with simultaneous lateral patellar cartilage/BML defects and inferior-medial patellar osteophyte size. A significant positive correlation between the degree of patella alta and SHFP oedema was detected (r = 0.259, p < 0.001). The presence of oedema was associated with 24-month cartilage volume loss (odds ratio (OR) 2.11, 95% confidence interval 1.46–3.06) and medial patellar BML size (OR 1.92 (1.15–3.21)) and number (OR 2.50 (1.29–4.88)) worsening. The optimal cut-off value for the grade of baseline SHFP oedema regarding both presence and worsening of patellar structural damage was ≥ 1 (presence of any SHFP hyperintensity).

Conclusions

The presence of SHFP oedema could be considered as a predictor of future patellar cartilage loss and BML worsening, and an indicator of simultaneous cartilage, BML and osteophyte defects.

Key Points

• SHFP oedema was associated with simultaneous lateral patellar OA-related structural damage.

• SHFP oedema was associated with longitudinal patellar cartilage loss over 24 months.

• SHFP oedema could be considered as indicator and predictor of patellar OA.

Keywords

Cartilage Knee Magnetic resonance imaging Osteoarthritis Patella 

Abbreviations

2D

Two-dimensional

ACL

Anterior cruciate ligament

ANOVA

Analysis of variance

AUC

Area under the curve

BMI

Body mass index

BML

Bone marrow lesion

CI

Confidence interval

DESS

Dual echo at steady state

FNIH

Foundation for the National Institute of Health

IS

Insall–Salvati ratio

IW

Intermediate weighted

JSL

Joint space loss

KL

Kellgren–Lawrence

MOAKS

Magnetic resonance imaging osteoarthritis knee score

MOST

Multicenter Osteoarthritis Study

MPR

Multiplanar reconstruction

MRI

Magnetic resonance imaging

OA

Osteoarthritis

OAI

Osteoarthritis Initiative

OR

Odds ratio

PASE

Physical activity scale for elderly

RCI

Reliable change index

ROC

Receiver operating characteristic

SD

Standard deviation

SE

Standard error

SHFP

Superolateral Hoffa’s fat pad

TGD

Trochlear groove depth

TSE

Turbo spin echo

TTTG

Tibial tuberosity trochlear groove

WE

Water excitation

WOMAC

Western Ontario & McMaster Universities osteoarthritis

WORMS

Whole-organ magnetic resonance score

Notes

Acknowledgments

The authors would like to thank the study participants and the staff involved in FNIH projects.

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Dr. Ali Guermazi.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was not required for this study because we used an open access OAI database. All enrolled subjects in the OAI study gave informed consent.

Ethical approval

Institutional review board approval was not required because we used an open access OAI database. The OAI study has received ethics board approval by the institutional review board at the University of California, San Francisco (OAI Coordinating Centre; Approval Number 10-00532).

Study subjects or cohorts overlap

Some study subjects or cohorts have been previously reported in the OAI database and OAI-related articles.

Methodology

• prospective

• observational

• multicentre study

Supplementary material

330_2018_5334_MOESM1_ESM.docx (26 kb)
ESM 1 (DOCX 26 kb)

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  • Arya Haj-Mirzaian
    • 1
  • Ali Guermazi
    • 2
  • Nima Hafezi-Nejad
    • 3
  • Christopher Sereni
    • 4
  • Michael Hakky
    • 5
  • David J. Hunter
    • 6
  • Bashir Zikria
    • 7
  • Frank W. Roemer
    • 2
    • 8
  • Shadpour Demehri
    • 1
  1. 1.Russell H. Morgan Department of Radiology and Radiological ScienceJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of RadiologyBoston University School of MedicineBostonUSA
  3. 3.School of MedicineUniversity System of Maryland (USM)BaltimoreUSA
  4. 4.Department of RadiologyUniversity of Massachusetts Medical SchoolBostonUSA
  5. 5.Department of RadiologyFlorida HospitalMaitlandUSA
  6. 6.Rheumatology Department, Royal North Shore Hospital SydneyUniversity of SydneySydneyAustralia
  7. 7.Department of Orthopaedic SurgeryJohns Hopkins UniversityBaltimoreUSA
  8. 8.Department of RadiologyUniversity of Erlangen-NurembergErlangenGermany

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