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Self-controlled super-selective arterial spin labelling

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Abstract

Objectives

Arterial spin labelling (ASL) is a method of non-contrast-enhanced perfusion imaging that is generally based on the acquisition of two images which must be subtracted in order to obtain perfusion-weighted images. This is also the case for some flow territory mapping approaches that require the acquisition of two images for each artery of interest, thereby prolonging scan time and yielding largely redundant information. The aim of this study is to accelerate flow territory mapping using ASL by eliminating the acquisition of a control condition.

Methods

Using super-selective ASL, only one artery of interest is tagged, while the contralateral arteries are in a state similar to the control condition. By using an arithmetic combination of the label images of all territories, selective images of flow territories can be obtained without the need to acquire an additional control condition. This approach for obtaining artery-selective perfusion-weighted images without acquiring a control condition is presented in this study and is referred to as "self-controlled super-selective ASL".

Results

Quantitative perfusion measurements were similar to conventional super-selective and non-selective perfusion imaging across all subjects.

Conclusion

Super-selective arterial spin labelling can be performed without acquiring a control image.

Key Points

• An accelerated method of flow territory mapping is presented.

• Super-selective arterial spin labelling is performed without a control condition.

• A new approach for calculating individual flow territories is presented.

• The presented technique is compared to established approaches.

• The outcome is similar to that using conventional techniques.

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Funding

This study has received funding from the German Research Foundation (DFG), grant no. JA 875/7-1.

Author information

Authors and Affiliations

  1. Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein Campus Kiel, Arnold-Heller-Str. 3, 24103, Kiel, Germany

    Thomas Lindner, Friederike Austein & Olav Jansen

  2. Philips GmbH Innovative Technologies Research Laboratories, Röntgenstraße 24-26, 22335, Hamburg, Germany

    Michael Helle

Authors
  1. Thomas Lindner
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  2. Friederike Austein
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  3. Olav Jansen
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  4. Michael Helle
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Corresponding author

Correspondence to Thomas Lindner.

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Guarantor

The scientific guarantor of this publication is Prof. Dr. med. Olav Jansen.

Conflict of interest

The authors of this manuscript declare relationships with the following companies:

Dr. Michael Helle is employed at Philips Research Laboratories, Hamburg, Germany.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional review board approval was obtained.

Study subjects or cohorts overlap

Some study subjects or cohorts were previously reported in the 2016 Congress of the German Society of Neuroradiology and Congress of the 2017 International Society of Magnetic Resonance in Medicine.

Methodology

• prospective

• experimental

• performed at one institution

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Lindner, T., Austein, F., Jansen, O. et al. Self-controlled super-selective arterial spin labelling. Eur Radiol 28, 1227–1233 (2018). https://doi.org/10.1007/s00330-017-5066-7

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  • DOI: https://doi.org/10.1007/s00330-017-5066-7

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