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Glomerulonephritis and Coombs-positive hemolytic anemia mimicking scleroderma renal crisis in an overlap of systemic lupus erythematosus and diffuse systemic sclerosis

  • Ali TaylanEmail author
  • Emel Tekin
  • Bahar Engin
Case Based Review

Abstract

Systemic sclerosis (SSc) may overlap frequently with other rheumatic diseases, including systemic lupus erythematosus (SLE), which can require high-dose steroids depending on the clinical presentation. We present a case involving this overlap in which the patient concomitantly developed lupus nephritis and Coombs (+) hemolytic anemia, which was confused with scleroderma renal crisis. In this condition, assessing for lupus nephritis with timely renal biopsy and lupus serology can aid in guiding the appropriate treatment. We discuss the clinical features and challenging management of this case with a review of the English-language literature for SSc and SLE overlap with glomerulonephritis.

Keywords

Systemic sclerosis and systemic lupus erythematosus overlap Glomerulonephritis Hemolytic anemia Scleroderma renal crisis 

Notes

Author contributions

Conception and design of this study: all authors. Interpretation of results and drafting the manuscript: T.A, E.B Acquisition of data: E.B, Y.E Critical revision of manuscript: T.A Manuscript approval: all authors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the individual participant included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Rheumatology, Izmir Tepecik Training and Research HospitalSaglik Bilimleri UniversityIzmirTurkey
  2. 2.Department of Pathology, Izmir Tepecik Training and Research HospitalSaglik Bilimleri UniversityIzmirTurkey
  3. 3.Department of Internal Medicine, Izmir Tepecik Training and Research HospitalSaglik Bilimleri UniversityIzmirTurkey

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