Rheumatology International

, Volume 39, Issue 7, pp 1279–1284 | Cite as

Urethral involvement in granulomatosis with polyangiitis: a case-based review

  • Hamdy M. A. AhmedEmail author
  • Mohanad M. Elfishawi
  • Ahmed Hagiga
  • Ibrahim M. A. Ahmed
  • Ya Li Chen
Cases with a Message


Granulomatosis with polyangiitis (GPA) commonly presents with glomerulonephritis and inflammation of upper and lower respiratory tracts. It can also involve other organs including those of the urinary tract. The involvement of the urethra is very rarely reported. We present a case of GPA in a patient who had recurrent urinary tract infections and an acute bladder outlet obstruction due to a urethral thickening by GPA. In this report, we discuss urethral involvement with GPA. The incidence of such involvement, as with other urinary tract organs, might be underestimated. It can affect both sexes, with male predominance, and can occur at any age. It responds to standard GPA medical treatment but may require surgical intervention. Rheumatologists should be aware of this limited form of GPA as early recognition and treatment can decrease the risk of complications.


Granulomatosis with polyangiitis GPA Wegener’s Urogenital Urethra Limited form 



The authors would like to express sincere gratitude to Dr. Alvin Lee Day for reviewing the manuscript and constructive feedback.

Author contributions

HMAA and YLC have summarized the case presentation. IMAA has translated the French case report into English. All authors have contributed to the literature review and to the manuscript.


Nothing to declare.

Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Rheumatology, Department of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of Medicine, New York City Health Hospitals, QueensIcahn School of Medicine at Mount SinaiNew YorkUSA
  3. 3.Chelsea and Westminster Hospital NHS Foundation TrustLondonUK
  4. 4.Faculty of MedicineUniversity of BenhaBenhaEgypt
  5. 5.Division of Rheumatology, Department of MedicineRochester Regional Health SystemRochesterUSA

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