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Rheumatology International

, Volume 39, Issue 4, pp 707–713 | Cite as

Reliability of OMERACT ultrasound elementary lesions in gout: results from a multicenter exercise

  • Tomas CazenaveEmail author
  • Victoria Martire
  • Anthony M. Reginato
  • Marwin Gutierrez
  • Christian Alfredo Waimann
  • Carlos Pineda
  • Javier Eduardo Rosa
  • Santiago Ruta
  • Oscar Sedano-Santiago
  • Ana Maria Bertoli
  • Marcelo Audisio
  • Cristina Hernandez-Diaz
  • Lucio Ventura-Rios
  • Maritza Quintero
  • Eugenio De Miguel
  • Ana Laura Alvarez-del-Castillo-Araujo
  • Andy Abril
  • Eliana Natalí Ayala-Ledesma
  • Edith Alarcon-Isidro
  • Maria Lida Santiago
  • Mariana Alejandra Pera
  • Cecilia Urquiola
  • Gustavo Rodriguez Gil
  • Lina Maria Saldarriaga Rivera
  • Cesar Cefferino
  • Mariana Benegas
  • Mario Enrique Diaz Cortes
  • Maximiliano Bravo
  • Diana Peiteado
  • Natalia Anahi Estrella
  • Roser Areny Micas
  • Jorge Saavedra Muñoz
  • Rodolfo del Carmen Arape Toyo
  • Maria Soledad Gálvez Elkin
  • Walter Javier Spindler
  • Clarisa Sandobal
  • Josefina Marin
  • Manuella Lima Gomes Ochtrop
  • Ricardo Pavao Ayala
  • Erika Roxana Catay
  • Guillermo Enrique Py
  • Gabriel Hector Aguilar
  • Yvonne Yona Rengel Colina
  • Carla Antonela Airoldi
  • Claudia Selene Mora-Trujillo
  • Maria Paula Kohan
  • Lorena Evelin Urioste Eguez
  • Concepción Castillo-Gallego
  • Jose Francisco Diaz-Coto
  • Patricio Tate
  • Carla Magali Saucedo
  • Oscar Vega-Hinojosa
  • Cristian Jonatan Troitiño
  • Maria Florencia Marengo
  • Priscila Maria Marcaida
  • Irene Monjo Henry
  • Roberto Muñoz-Louis
  • Carla Solano
  • Felix Reinaldo Fernandez Castillo
  • Cesar Enrique Graf
  • Mara Guinsburg
  • Maria Julia Santa Cruz
  • David Alejandro Navarta Ortiz
  • Magaly Alva Linares
  • Marcos Gabriel Rosemffet
  • Pan-American League of Associations for Rheumatology (PANLAR) Ultrasound Study Group
Imaging

Abstract

The aim of this study was to evaluate the reliability of the outcome measures in rheumatology (OMERACT) definitions for ultrasound (US) elementary lesions in gout through an image reading exercise. Images from patients with gout (static images and videos) were collected. As an initial step, we carried out a image reading exercise within the experts of the Pan-American League of Associations for Rheumatology (PANLAR) US Study Group (n = 16). The following step consisted in a web-based exercise with the participation of larger number of sonographers (n = 63) from different centers. Images were rated evaluating the presence/absence of any US elementary lesion. Inter- and intra-reader reliabilities were analyzed using kappa coefficients. Participants were stratified according to their level of experience. In the first exercise, inter-reader kappa values were 0.45 for aggregates, 0.57 for tophus, 0.69 for erosions, and 0.90 for double contour (DC). Intra-reader kappa values were 0.86, 0.76, 0.80, and 0.90, respectively. The web-based exercise showed inter-reader kappa values for aggregates, tophus, erosions, and DC of 0.42, 0.49, 0.69, and 0.79, respectively. The intra-reader kappa values were 0.62, 0.69, 0.77, and 0.85, respectively. Reliability was not influenced by the sonographer’s level of experience. The reliability of the new OMERACT US definitions for elementary lesions in gout ranged from moderate to excellent, depending on the type of lesion.

Keywords

Gout Ultrasound Elementary lesions Reliability 

Notes

Funding

This study received no funding.

Compliance with ethical standards

Conflict of interest

Tomas Cazenave declares that he has no conflict of interest. Victoria Martire declares that she has no conflict of interest. Anthony M. Reginato declares that he has no conflict of interest. Marwin Gutierrez declares that he has no conflict of interest. Christian Alfredo Waimann declares that he has no conflict of interest. Carlos Pineda declares that he has no conflict of interest. Javier Eduardo Rosa declares that he has no conflict of interest. Santiago Ruta declares that he has no conflict of interest. Oscar Sedano-Santiago declares that he has no conflict of interest. Ana Maria Bertoli declares that she has no conflict of interest. Marcelo Audisio declares that he has no conflict of interest. Cristina Hernandez-Diaz declares that she has no conflict of interest. Lucio Ventura-Rios declares that he has no conflict of interest. Maritza Quintero declares that she has no conflict of interest. Eugenio De Miguel declares that he has no conflict of interest. Ana Laura Alvarez-del-Castillo-Araujo declares that she has no conflict of interest. Andy Abril declares that she has no conflict of interest. Eliana Natalí Ayala-Ledesma declares that she has no conflict of interest. Edith Alarcon-Isidro declares that she has no conflict of interest. Maria Lida Santiago declares that she has no conflict of interest. Mariana Alejandra Pera declares that she has no conflict of interest. Cecilia Urquiola declares that she has no conflict of interest. Gustavo Rodriguez Gil declares that he has no conflict of interest. Lina Maria Saldarriaga Rivera declares that she has no conflict of interest. Cesar Cefferino declares that he has no conflict of interest. Mariana Benegas declares that she has no conflict of interest. Mario Enrique Diaz Cortes declares that he has no conflict of interest. Maximiliano Bravo declares that he has no conflict of interest. Diana Peiteado declares that she has no conflict of interest. Natalia Anahi Estrella declares that she has no conflict of interest. Roser Areny Micas declares that she has no conflict of interest. Jorge Saavedra Muñoz declares that he has no conflict of interest. Rodolfo del Carmen Arape Toyo declares that he has no conflict of interest. Maria Soledad Gálvez Elkin declares that she has no conflict of interest. Walter Javier Spindler declares that he has no conflict of interest. Clarisa Sandobal declares that she has no conflict of interest. Josefina Marin declares that she has no conflict of interest. Manuella Lima Gomes Ochtrop declares that she has no conflict of interest. Ricardo Pavao Ayala declares that he has no conflict of interest. Erika Roxana Catay declares that she has no conflict of interest. Guillermo Enrique Py declares that he has no conflict of interest. Gabriel Hector Aguilar declares that he has no conflict of interest. Yvonne Yona Rengel Colina declares that she has no conflict of interest. Carla Antonela Airoldi declares that she has no conflict of interest. Claudia Selene Mora-Trujillo declares that she has no conflict of interest. Maria Paula Kohan declares that she has no conflict of interest. Lorena Evelin Urioste Eguez declares that she has no conflict of interest. Concepción Castillo-Gallego declares that she has no conflict of interest. Jose Francisco Diaz-Coto declares that he has no conflict of interest. Patricio Tate declares that he has no conflict of interest. Carla Magali Saucedo declares that she has no conflict of interest. Oscar Vega-Hinojosa declares that he has no conflict of interest. Cristian Jonatan Troitiño declares that he has no conflict of interest. Maria Florencia Marengo declares that she has no conflict of interest. Priscila Maria Marcaida declares that she has no conflict of interest. Irene Monjo Henry declares that she has no conflict of interest. Roberto Muñoz-Louis declares that he has no conflict of interest. Carla Solano declares that she has no conflict of interest. Felix Reinaldo Fernandez Castillo declares that he has no conflict of interest. Cesar Enrique Graf declares that he has no conflict of interest. Mara Guinsburg declares that she has no conflict of interest. Maria Julia Santa Cruz declares that she has no conflict of interest. David Alejandro Navarta Ortiz declares that he has no conflict of interest. Magaly Alva Linares declares that she has no conflict of interest. Marcos Gabriel Rosemffet declares that he has no conflict of interest.

Research involving human and/or animal participants

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Tomas Cazenave
    • 1
    Email author
  • Victoria Martire
    • 1
  • Anthony M. Reginato
    • 2
  • Marwin Gutierrez
    • 3
  • Christian Alfredo Waimann
    • 4
  • Carlos Pineda
    • 3
  • Javier Eduardo Rosa
    • 5
  • Santiago Ruta
    • 5
  • Oscar Sedano-Santiago
    • 6
  • Ana Maria Bertoli
    • 7
  • Marcelo Audisio
    • 8
  • Cristina Hernandez-Diaz
    • 3
  • Lucio Ventura-Rios
    • 3
  • Maritza Quintero
    • 9
  • Eugenio De Miguel
    • 10
  • Ana Laura Alvarez-del-Castillo-Araujo
    • 11
  • Andy Abril
    • 12
  • Eliana Natalí Ayala-Ledesma
    • 13
  • Edith Alarcon-Isidro
    • 14
  • Maria Lida Santiago
    • 15
  • Mariana Alejandra Pera
    • 16
  • Cecilia Urquiola
    • 17
  • Gustavo Rodriguez Gil
    • 17
  • Lina Maria Saldarriaga Rivera
    • 18
  • Cesar Cefferino
    • 19
  • Mariana Benegas
    • 20
  • Mario Enrique Diaz Cortes
    • 21
  • Maximiliano Bravo
    • 22
  • Diana Peiteado
    • 10
  • Natalia Anahi Estrella
    • 23
  • Roser Areny Micas
    • 24
  • Jorge Saavedra Muñoz
    • 25
  • Rodolfo del Carmen Arape Toyo
    • 26
  • Maria Soledad Gálvez Elkin
    • 27
  • Walter Javier Spindler
    • 28
  • Clarisa Sandobal
    • 29
  • Josefina Marin
    • 5
  • Manuella Lima Gomes Ochtrop
    • 30
  • Ricardo Pavao Ayala
    • 31
  • Erika Roxana Catay
    • 22
  • Guillermo Enrique Py
    • 8
  • Gabriel Hector Aguilar
    • 32
  • Yvonne Yona Rengel Colina
    • 33
  • Carla Antonela Airoldi
    • 34
  • Claudia Selene Mora-Trujillo
    • 35
  • Maria Paula Kohan
    • 36
  • Lorena Evelin Urioste Eguez
    • 37
  • Concepción Castillo-Gallego
    • 38
  • Jose Francisco Diaz-Coto
    • 39
  • Patricio Tate
    • 15
  • Carla Magali Saucedo
    • 40
  • Oscar Vega-Hinojosa
    • 41
  • Cristian Jonatan Troitiño
    • 42
  • Maria Florencia Marengo
    • 4
  • Priscila Maria Marcaida
    • 42
  • Irene Monjo Henry
    • 10
  • Roberto Muñoz-Louis
    • 43
  • Carla Solano
    • 44
  • Felix Reinaldo Fernandez Castillo
    • 45
  • Cesar Enrique Graf
    • 46
  • Mara Guinsburg
    • 17
  • Maria Julia Santa Cruz
    • 36
  • David Alejandro Navarta Ortiz
    • 47
  • Magaly Alva Linares
    • 35
  • Marcos Gabriel Rosemffet
    • 1
  • Pan-American League of Associations for Rheumatology (PANLAR) Ultrasound Study Group
  1. 1.Rheumatology UnitInstituto de Rehabilitación PsicofísicaBuenos AiresArgentina
  2. 2.Division of RheumatologyThe Warren Alpert School of Medicine at Brown UniversityProvidenceUSA
  3. 3.Division of Musculoskeletal and Rheumatic Diseases Instituto Nacional de RehabilitacionMexico CityMexico
  4. 4.Rheumatology SectionHospital Dr. Hector CuraOlavarriaArgentina
  5. 5.Rheumatology SectionHospital Italiano de Buenos AiresBuenos AiresArgentina
  6. 6.Escuela de Ecografia ECOSERMEDICLimaPeru
  7. 7.Instituto Reumatológico StrusbergCordobaArgentina
  8. 8.Rheumatology DepartmentHospital Nacional de ClínicasCordobaArgentina
  9. 9.Medicine SchoolUniversidad de Los Andes-Rheumatology Unit-IAHULAMeridaVenezuela
  10. 10.Hospital Universitario La PazMadridSpain
  11. 11.Reumatología Integral ClinicMonterreyMexico
  12. 12.Rheumatology DepartmentMayo ClinicJacksonvilleUSA
  13. 13.Rheumatology DepartmentHospital Nacional Arzobispo LoayzaLimaPeru
  14. 14.Rheumatology DepartmentHospital San Juan de LuriganchoLimaPeru
  15. 15.Rheumatology ClinicOrganización Medica de InvestigaciónBuenos AiresArgentina
  16. 16.Rheumatology DepartmentHospital General de Agudos de La PlataBuenos AiresArgentina
  17. 17.Rheumatology UnitHospital Municipal “Dr. Leónidas Lucero”Bahia BlancaArgentina
  18. 18.Rheumatology UnitHospital Universitario San JorgePereiraColombia
  19. 19.Rheumatology DepartmentHospital Nacional Dos de MayoLimaPeru
  20. 20.Rheumatology UnitHospital Julio MendezBuenos AiresArgentina
  21. 21.Rheumatology UnitHospital Universitario Fundación Santa FeBogotaColombia
  22. 22.Rheumatology Clinic MorenoFormosaArgentina
  23. 23.Rheumatology Clinic Centro Integral de Alta ComplejidadSaltaArgentina
  24. 24.Rheumatology UnitHospital Felix Bulnes CerdaSantiagoChile
  25. 25.Rheumatology DepartmentHospital San Juan de DiosSantiagoChile
  26. 26.Rheumatology UnitCentro Clínico la IsabelicaValenciaVenezuela
  27. 27.Rheumatology SectionInstituto de CardiologíaSantiago del EsteroArgentina
  28. 28.Rheumatology UnitCentro Medico PrivadoTucumanArgentina
  29. 29.Rheumatolgy SectionHospital Jose Maria CullenSanta FeArgentina
  30. 30.Rheumatology DepartmentHospital Universitário Pedro ErnestoRio de JaneiroBrazil
  31. 31.Rheumatology UnitGREMEDAArtigasUruguay
  32. 32.Musculoskeletal Imaging UnitCentro RossiBuenos AiresArgentina
  33. 33.Rheumatology UnitYReuma Centro PrivadoBarquisimetoVenezuela
  34. 34.Rheumatology DepartmentHospital ProvincialRosarioArgentina
  35. 35.Rheumatology DepartmentHospital Nacional Edgardo Rebagliati MartinsLimaPeru
  36. 36.Rheumatology DepartmentHospital General de Agudos E. TornuBuenos AiresArgentina
  37. 37.Rheumatology UnitReumatología Diagnostica EspecializadaSanta CruzBolivia
  38. 38.Rheumatology DepartmentComplejo Hospitalario TorrecárdenasAlmeriaSpain
  39. 39.Rheumatology UnitHospital MexicoSan JoseCosta Rica
  40. 40.Rheumatology SectionHospital Anita ElicagarayAdolfo Gonzales ChavesArgentina
  41. 41.Rheumatology UnitReumacenter and EssaludJuliacaPeru
  42. 42.Rheumatology UnitHospital Bernardino RivadaviaBuenos AiresArgentina
  43. 43.Rheumatology UnitHospital Docente Padre BilliniSanto DomingoDominican Republic
  44. 44.Rheumatology UnitHospital Nacional RosalesSan SalvadorEl Salvador
  45. 45.Rheumatology UnitClinica RazettiBarquisimetoVenezuela
  46. 46.Rheumatology UnitCentro Médico MitreParanaArgentina
  47. 47.Rheumatology UnitHospital Dr. Marcial V. QuirogaSan JuanArgentina

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