Rheumatology International

, Volume 39, Issue 2, pp 239–243 | Cite as

Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept

  • Elena Generali
  • Greta Carrara
  • Marinos Kallikourdis
  • Gianluigi Condorelli
  • Alessandra Bortoluzzi
  • Carlo A. Scirè
  • Carlo SelmiEmail author
Observational Research


To estimate biologic influence on heart failure (HF) risk in rheumatoid arthritis. Retrospective cohort (RECORD Study of Italian Society for Rheumatology) study on administrative healthcare databases. We identified 2527 patients treated with either etanercept (n = 1690) or abatacept (n = 837). HF incidence rate was higher in the abatacept cohort than in the etanercept cohort with a 2.38 (95% CI 1.08–5.27) crude competing risk HR (SHR) for abatacept of developing HF, not confirmed after adjustment for prespecified confounders (SHR 1.43; 95% CI 0.51–3.98). Abatacept, compared to etanercept, is prescribed to patients with a worse cardiovascular profile but does not increase the risk of developing HF, when confounding factors are accounted for.


Cardiovascular Epidemiology DMARDs Biologic 


Author contributions

EG, GC, AB, CS, CAS, MK, GC designed the idea, designed and supervised the project. EG, CS, GC, CAS, AB contributed to data analysis. EG, GC, AB CS, CAS, MK, GC critically reviewed and provided valuable input. All authors read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

EG, GC, MK, GC, AB, CAS have none to declare; Carlo Selmi has been consulting for BMS and Pfizer.

Ethical approval

The present work was approved by IRB of University of Pavia, Italy (deliberation of 12/03/2012).


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Rheumatology and Clinical ImmunologyHumanitas Clinical and Research CenterMilanItaly
  2. 2.Epidemiology UnitItalian Society for RheumatologyMilanItaly
  3. 3.Laboratory of Adaptive ImmunityHumanitas Clinical and Research CenterMilanItaly
  4. 4.Humanitas UniversityRozzanoItaly
  5. 5.Department of Cardiovascular MedicineHumanitas Clinical and Research CenterMilanItaly
  6. 6.University of FerraraFerraraItaly
  7. 7.BIOMETRA Department, University of MilanMilanItaly

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