Evaluation of six-minute walk test in juvenile systemic sclerosis
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The objective is to evaluate the walking distance and oxygen desaturation during the six-minute walk test and to establish correlations between the test results and other clinical findings so to assess the reliability of the test for evaluation of children with juvenile systemic sclerosis (jSSc). A total of 25 jSSc, 27 juvenile systemic lupus erythematosus (jSLE), and 30 healthy controls were included. The test is conducted according to the guidelines recommended by the American Thoracic Society, standardized in 2002. Median values of walking distances were 470 (415–580) m in jSSc; 518 (376–618) m in jSLE; and 562 (493.5–618) m in healthy controls. jSSc patients walked significantly less distance comparing to controls (p < 0.001). jSSc patients with lung involvement walked less than those without lung involvement [463.2 (418–565) m vs. 491.5 (415–580) m], but without a significant difference (p = 0.82). The frequency of lower extremity pain during and after the test was significantly higher in the jSSc cohort compared to both control groups (p = 0.001). Patients with myalgia were found to walk less than those without myalgia [446.5 (415–538) m vs. 493.5 (428–580) m] (p = 0.04). Patients with jSSc have limited walking distances. Despite the decreased walking distance among jSSc patients with ILD and/or PAH, the limited number of patients makes the results inappropriate for interpretation. Low extremity pain influences the walking capacity of jSSc patients.
KeywordsPediatric systemic sclerosis Six-minute walk test Pulmonary arterial hypertension Interstitial lung disease
OK contributed to the conception and design of the study, interpretation of the data, OK and AA contributed to the data collection, data analysis and drafting article, KB and REO contributed to the acquisition and evaluation of the data, MY and SS participated in data collection and performing the statistical analysis. All authors read and approved the manuscript.
This review was not funded by any person or corporation.
Compliance with ethical standards
Conflict of interest
Author O.K, Author A.A, Author S.S, Author M.Y, Author K.B, Author R.E.O, and Author O.K declare that they have no conflict of interest including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials.
Approval was obtained for the study from the Ethics Committee of the Cerrahpasa Medical School (approved: 08/02/2018-53142). Informed consent was obtained from all individual participants included in the study. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.
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