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Observational study and brief analysis of diagnostic criteria in relapsing polychondritis

  • Thomas Rose
  • Udo Schneider
  • Martina Bertolo
  • Jens Klotsche
  • Vincent Casteleyn
  • Robert Biesen
  • Gerd R. Burmester
  • Falk Hiepe
Observational Research

Abstract

Observational study of patients with relapsing polychondritis (RPC) and brief evaluation of widely used diagnostic criteria. A retrospective analysis of 18 patients with RPC treated in the past 15 years at the Charté—Universitätsmedizin Berlin was performed. Three different diagnostic criteria were applied to our cohort. Sensitivities of diagnostic criteria of McAdam et al., Damiani and Levine and Michet et al. were calculated as well as the 5- and 10-year survival. Analysis of diagnostic criteria revealed a sensitivity of 88.9% using Damiani and Levine criteria, 66.7% for Michet et al. and 50% for McAdam et al., respectively. Modifying the criteria of Michet et al. increases the sensitivity to 88.9%. The 5- and 10-year survival were 100 and 90.9%, respectively. Current diagnostic criteria in RPC should be reappraised covering the diversity of clinical findings with the aim to improve clinical care and research in RPC.

Keywords

Relapsing polychondritis Survival Diagnosis Criteria Inflammation 

Notes

Acknowledgements

The authors thank Anna R. Lisney for proof-reading of the manuscript.

Compliance with ethical standards

Conflict of interest

All authors have no financial or competing interests to declare. We received no financial support or other benefits from commercial sources for the reported work on the manuscript.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Thomas Rose
    • 1
  • Udo Schneider
    • 1
  • Martina Bertolo
    • 2
  • Jens Klotsche
    • 3
  • Vincent Casteleyn
    • 1
  • Robert Biesen
    • 1
  • Gerd R. Burmester
    • 1
  • Falk Hiepe
    • 1
  1. 1.Department of Rheumatology and Clinical ImmunologyCharité Universitätsmedizin BerlinBerlinGermany
  2. 2.Department of NephrologyCharité Universitätsmedizin BerlinBerlinGermany
  3. 3.German Rheumatism Research CenterBerlin-Leibniz InstituteBerlinGermany

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