Observational study and brief analysis of diagnostic criteria in relapsing polychondritis
- 98 Downloads
Observational study of patients with relapsing polychondritis (RPC) and brief evaluation of widely used diagnostic criteria. A retrospective analysis of 18 patients with RPC treated in the past 15 years at the Charté—Universitätsmedizin Berlin was performed. Three different diagnostic criteria were applied to our cohort. Sensitivities of diagnostic criteria of McAdam et al., Damiani and Levine and Michet et al. were calculated as well as the 5- and 10-year survival. Analysis of diagnostic criteria revealed a sensitivity of 88.9% using Damiani and Levine criteria, 66.7% for Michet et al. and 50% for McAdam et al., respectively. Modifying the criteria of Michet et al. increases the sensitivity to 88.9%. The 5- and 10-year survival were 100 and 90.9%, respectively. Current diagnostic criteria in RPC should be reappraised covering the diversity of clinical findings with the aim to improve clinical care and research in RPC.
KeywordsRelapsing polychondritis Survival Diagnosis Criteria Inflammation
The authors thank Anna R. Lisney for proof-reading of the manuscript.
Compliance with ethical standards
Conflict of interest
All authors have no financial or competing interests to declare. We received no financial support or other benefits from commercial sources for the reported work on the manuscript.
- 2.Lekpa FK, Chevalier X (2018) Refractory relapsing polychondritis: challenges and solutions. In: Open Access Rheumatol. Res. Rev. https://www.dovepress.com/refractory-relapsing-polychondritis-challenges-and-solutions-peer-reviewed-fulltext-article-OARRR. Accessed 20 Mar 2018
- 14.Trentham DE (1998) Relapsing polychondritis. Ann Intern Med 129:114. https://doi.org/10.7326/0003-4819-129-2-199807150-00011 CrossRefPubMedGoogle Scholar